Product image of Lamotrigina Aurobindo (Lamotrigine) supplied by GNH India

Lamotrigina Aurobindo

Active Ingredient:
Lamotrigine
Origin:
EU

Lamotrigina Aurobindo (Lamotrigine)

Lamotrigine, the active ingredient in Lamotrigina Aurobindo, is an anticonvulsant presented as an oral tablet for oral use. It is indicated for the treatment of partial seizures in epilepsy and as maintenance therapy for bipolar disorder in adults.
GNH India supplies Lamotrigina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Lamotrigine is used in neurological and psychiatric conditions that involve abnormal neuronal excitability.

  • Epilepsy (partial seizures): reduces seizure frequency and severity in patients with focal onset seizures.
  • Bipolar disorder (maintenance therapy): stabilises mood and lowers the risk of depressive or manic episode recurrence.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, which stabilises neuronal membranes and diminishes the release of excitatory neurotransmitters such as glutamate. This reduction in neuronal firing helps control seizure activity and modulates mood‑related pathways in bipolar disorder.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Blurred vision
  • Fatigue
  • Skin rash

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe skin reactions (e.g., bullous pemphigoid)
  • Blood dyscrasias such as agranulocytosis
  • Hepatic failure
  • Suicidal ideation or behaviour
  • Severe hypersensitivity reactions

Precautions & Warnings

Before initiating lamotrigine therapy, consider the following safety measures.

  • Dose titration: increase gradually to minimise the risk of rash.
  • Monitor skin: watch for any new rash or hypersensitivity signs.
  • Avoid abrupt discontinuation: sudden stop may increase seizure frequency.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Pregnancy: risk category unknown; discuss benefits and risks with a healthcare professional.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamotrigine interacts with several medicines that can alter its plasma concentration or increase toxicity.

Major Interactions (Avoid)

  • Valproate: raises lamotrigine levels, increasing rash risk.
  • Carbamazepine: lowers lamotrigine levels, potentially reducing efficacy.
  • Phenobarbital: decreases lamotrigine concentrations, may require dose increase.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may increase lamotrigine clearance, necessitating dose adjustment.
  • Serotonergic agents: monitor for signs of serotonin syndrome.
  • Other antiepileptics (e.g., phenytoin, primidone): may require therapeutic monitoring and dose modifications.

Frequently Asked Questions

Lamotrigina Aurobindo contains lamotrigine, which is prescribed for partial (focal) seizures in epilepsy and as a maintenance treatment to stabilise mood in adults with bipolar disorder. The drug helps reduce seizure frequency and prevents recurrence of depressive or manic episodes.

Lamotrigine blocks voltage‑gated sodium channels on neurons, which stabilises the neuronal membrane and reduces the release of excitatory neurotransmitters such as glutamate. This action dampens abnormal electrical activity that underlies seizures and modulates pathways involved in mood regulation.

The appropriate dose of lamotrigine is determined individually by a prescriber based on the patient’s condition, age, renal and hepatic function, and any concomitant medications. Dosage titration is typically gradual to minimise the risk of skin reactions.

The safety of lamotrigine in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against possible risks and may adjust therapy or provide close monitoring if treatment is required during pregnancy or while breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamotrigine differs from many antiepileptics by primarily targeting sodium channels and having a favourable cognitive profile. Compared with carbamazepine or phenytoin, it has a lower incidence of sedation but requires careful titration to avoid skin reactions. Its mood‑stabilising properties also make it unique for bipolar disorder.

Lamotrigina Aurobindo should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

The product is taken orally, usually as a tablet, with or without food as directed by the prescribing clinician. Swallow the tablet whole with water; do not crush or chew unless the prescriber advises otherwise.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias, hepatic failure, and the emergence of suicidal thoughts or behaviours. Prompt medical attention is required if any of these symptoms develop.

Lamotrigina Aurobindo is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Patients with a history of severe rash to lamotrigine, or those taking interacting medications that cannot be adjusted, should avoid its use unless supervised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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