Lamotrigina Kern Pharma (Lamotrigine)

Lamotrigine works by inhibiting voltage‑gated sodium channels on neuronal membranes, which reduces the rapid influx of sodium during depolarisation. This stabilises neuronal excitability and limits the release of excitatory neurotransmitters such as glutamate, thereby decreasing seizure activity and supporting mood regulation.

The dosage of lamotrigine is individualised by the prescribing healthcare professional based on the patient’s age, weight, renal and hepatic function, and the specific condition being treated. The prescriber determines the starting dose, titration schedule, and maintenance dose.

Lamotrigine is classified as pregnancy category B, indicating that animal studies have not shown risk and there are limited human data. It may be used during pregnancy only when the potential benefit outweighs the risk. Limited information is available for breastfeeding; clinicians should weigh the benefits against possible exposure to the infant.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Compared with older agents such as carbamazepine or valproic acid, lamotrigine has a lower risk of weight gain and certain metabolic side effects. However, it requires careful titration to minimise skin‑reaction risk, especially when used with valproic acid. Its broad spectrum efficacy makes it useful for both focal and generalized seizures, as well as bipolar disorder maintenance.

Store the product at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in humid or excessively hot environments, and discard any tablets that appear discoloured or damaged.

Lamotrigine is administered orally as a tablet. Patients should swallow the tablet whole with water, with or without food, as directed by the prescriber. The dose is usually titrated gradually to the target maintenance level to reduce the risk of skin reactions.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias like agranulocytosis, hepatic failure, and the emergence of suicidal thoughts or behaviours. Prompt medical attention is required if any of these symptoms develop.

Lamotrigine should not be used by individuals with a known hypersensitivity to the drug or any of its components. Caution is advised in patients with severe hepatic impairment, and it is contraindicated in those who have previously experienced serious skin reactions to lamotrigine or related medications.