Product image of Lamotrigine Aurobindo (Lamotrigine) supplied by GNH India

Lamotrigine Aurobindo

Active Ingredient:
Lamotrigine
Origin:
EU

Lamotrigine Aurobindo (Lamotrigine)

Lamotrigine, the active ingredient in Lamotrigine Aurobindo, is an antiepileptic presented as a tablet for oral use. It is indicated for the treatment of various seizure types and for maintenance therapy in bipolar I disorder.
GNH India supplies Lamotrigine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

Lamotrigine is an antiepileptic medication used to manage seizure disorders and mood stabilization.

  • Partial seizures: reduces seizure frequency in patients with focal onset seizures.
  • Generalized tonic‑clonic seizures: helps control convulsive episodes in generalized epilepsy.
  • Lennox‑Gastaut syndrome: decreases seizure burden in this severe childhood epilepsy.
  • Bipolar I disorder (maintenance therapy): stabilizes mood and lowers risk of manic or depressive episodes.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, which stabilizes neuronal membranes and diminishes the release of excitatory neurotransmitters such as glutamate. This reduction in neuronal hyperexcitability underlies its anticonvulsant and mood‑stabilizing effects.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Rash or skin irritation.
  • Headache.
  • Dizziness or vertigo.
  • Nausea or gastrointestinal discomfort.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe hypersensitivity reactions including fever and organ involvement.
  • Hematologic abnormalities such as aplastic anemia or agranulocytosis.

Precautions & Warnings

Before initiating lamotrigine therapy, consider the following safety measures.

  • Monitor skin reactions: discontinue if rash progresses or is severe.
  • Assess hepatic function: adjust use in patients with liver impairment.
  • Review concomitant medications: enzyme inducers or inhibitors may alter levels.
  • Counsel women of childbearing potential: discuss risks and alternatives.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamotrigine can interact with several drugs, affecting its plasma concentration and safety profile.

Major Interactions (Avoid)

  • Valproic acid: markedly increases lamotrigine levels, raising risk of severe rash.
  • Carbamazepine: reduces lamotrigine concentrations, potentially decreasing efficacy.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may lower lamotrigine levels, requiring dose adjustment.
  • Other enzyme inducers (e.g., phenytoin, phenobarbital): can decrease lamotrigine exposure.
  • Serotonergic agents: monitor for additive central nervous system effects.

Frequently Asked Questions

Lamotrigine Aurobindo is prescribed to treat partial seizures, generalized tonic‑clonic seizures, Lennox‑Gastaut syndrome, and as maintenance therapy for bipolar I disorder. It helps reduce seizure frequency and stabilizes mood in these recognized indications.

Lamotrigine blocks voltage‑gated sodium channels on neurons, which stabilizes the neuronal membrane and limits the release of excitatory neurotransmitters such as glutamate. This action reduces neuronal hyper‑excitability, providing anticonvulsant and mood‑stabilizing effects.

The specific dose of Lamotrigine Aurobindo is determined by the prescribing clinician based on the patient’s condition, age, weight, and concomitant medications. Dosage titration follows established clinical guidelines to balance efficacy and safety.

Safety of lamotrigine during pregnancy or lactation should be evaluated by a healthcare professional. While some data suggest relative safety, potential risks to the fetus or infant exist, and the benefits must be weighed against possible harms.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lamotrigine offers a broad spectrum of seizure control and mood‑stabilizing properties, with a lower risk of cognitive side effects compared with some older antiepileptics. However, it carries a unique risk of severe skin reactions, which requires careful monitoring, especially when combined with certain enzyme‑inducing agents.

Lamotrigine Aurobindo should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining a stable ambient temperature helps preserve the tablet’s potency and safety.

Lamotrigine Aurobindo is taken orally, usually as a tablet, with or without food as directed by the prescriber. The medication is typically started at a low dose and gradually increased to the target dose to minimize the risk of rash.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare hematologic disorders like aplastic anemia. Immediate medical attention is required if any signs of rash, fever, or unexplained bruising appear.

Lamotrigine Aurobindo is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its components. Caution is also advised for patients with a history of severe skin reactions, significant hepatic impairment, or those taking interacting medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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