Product image of Lanalget Retard (Tramadol Hydrochloride) supplied by GNH India

Lanalget Retard

Active Ingredient:
Tramadol Hydrochloride
Origin:
EU

Lanalget Retard (Tramadol Hydrochloride)

Tramadol Hydrochloride, the active ingredient in Lanalget Retard, is an opioid analgesic presented as an oral tablet for oral use. It is indicated for the management of moderate to severe pain in adult patients when other analgesics are insufficient.
GNH India supplies Lanalget Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

  • Tramadol Hydrochloride is used to manage pain within the moderate to severe pain pathway.
  • Post‑operative pain: provides analgesia after surgical procedures.
  • Chronic musculoskeletal pain: reduces persistent pain associated with conditions such as osteoarthritis.
  • Cancer‑related pain: alleviates moderate to severe pain in oncology patients.

How It Works

  • Tramadol Hydrochloride acts centrally by weakly stimulating μ‑opioid receptors while simultaneously inhibiting the reuptake of serotonin and norepinephrine. This dual action enhances descending inhibitory pain pathways in the spinal cord, leading to reduced perception of painful stimuli without a strong opioid effect.

Side Effects

Tramadol Hydrochloride may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Dizziness
  • Constipation
  • Somnolence
  • Headache
  • Dry mouth

Serious or Rare Side Effects

  • Seizures
  • Respiratory depression
  • Serotonin syndrome
  • Severe allergic reactions (e.g., rash, angioedema)
  • Hypotension
  • Dependence or addiction potential

Precautions & Warnings

When prescribing Tramadol Hydrochloride, several safety considerations are required.

  • Assess renal and hepatic function: adjust use in patients with impairment.
  • Avoid in patients with a history of seizures: risk may increase.
  • Concurrent CNS depressants: monitor for enhanced sedation and respiratory effects.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Potential for dependence: limit duration and monitor usage.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Tramadol Hydrochloride interacts with several drug classes that may alter its safety or efficacy.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome.
  • SSRIs or other serotonergic agents: increased serotonin toxicity.
  • CNS depressants (benzodiazepines, alcohol): profound sedation and respiratory depression.
  • CYP2D6 inhibitors (e.g., quinidine): may raise tramadol plasma levels.
  • Serotonergic drugs (triptans, linezolid): heightened serotonin syndrome risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampin, carbamazepine): may reduce analgesic effect.
  • Diuretics: may enhance hypotensive response.
  • Anticoagulants: monitor for bleeding if gastrointestinal side effects occur.

Frequently Asked Questions

Lanalget Retard contains tramadol hydrochloride and is prescribed to relieve moderate to severe pain, such as post‑operative discomfort, chronic musculoskeletal pain, or cancer‑related pain, when non‑opioid analgesics are inadequate.

Tramadol acts centrally by weakly stimulating μ‑opioid receptors and by blocking the reuptake of serotonin and norepinephrine. This combined effect enhances the body’s natural pain‑inhibiting pathways, reducing the perception of pain.

The appropriate dose of Lanalget Retard is determined by the prescribing clinician based on the patient’s pain severity, medical history, and response to therapy. Dosage adjustments may be needed for renal or hepatic impairment.

Safety data for tramadol in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Lanalget Retard, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stronger opioids, tramadol offers a milder μ‑opioid effect and adds serotonergic and noradrenergic activity, which may provide broader pain relief with a different side‑effect profile. It is often chosen when a balance between efficacy and lower risk of respiratory depression is desired.

Lanalget Retard should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, heat and direct sunlight to maintain potency and stability.

Lanalget Retard is taken orally, usually with a full glass of water. It may be taken with or without food, but consistent administration with respect to meals can help reduce gastrointestinal discomfort.

Serious risks include respiratory depression, seizures, serotonin syndrome (especially when combined with serotonergic drugs), severe allergic reactions, and the potential for dependence or abuse. Patients should be monitored closely for these events, particularly during dose escalation.

Lanalget Retard is contraindicated in patients with known hypersensitivity to tramadol, those taking monoamine oxidase inhibitors, or individuals with uncontrolled epilepsy. Caution is also advised for patients with severe respiratory disorders, severe hepatic or renal impairment, and in the elderly.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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