Product image of Lanirapid (Metildigoxin) supplied by GNH India

Lanirapid

Active Ingredient:
Metildigoxin
Origin:
EU

Lanirapid (Metildigoxin)

Metildigoxin, the active ingredient in Lanirapid, is a cardiac glycoside presented as an oral tablet for prescription use. It is employed to improve cardiac contractility in patients with certain heart rhythm disorders and chronic heart failure. By inhibiting the Na⁺/K⁺‑ATPase pump, it increases intracellular calcium, thereby strengthening myocardial contraction and providing rate control in atrial arrhythmias.

GNH India supplies Lanirapid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across the European market.

Manufacturer / TM Owner

Kern Pharma, S.L.

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Indications & Clinical Uses

Metildigoxin acts on the cardiac conduction system and myocardial contractility, making it useful in several cardiovascular conditions.

  • Chronic heart failure: improves ventricular contractility and reduces symptoms of fluid overload.
  • Atrial fibrillation (rate control): slows ventricular response by increasing vagal tone.
  • Supraventricular tachycardia: assists in rhythm control by enhancing atrioventricular nodal refractory period.

How It Works

  • Metildigoxin binds to the extracellular domain of the Na⁺/K⁺‑ATPase pump on cardiac myocytes, inhibiting its activity. This inhibition raises intracellular sodium, which reduces the activity of the sodium‑calcium exchanger, leading to an accumulation of intracellular calcium. The increased calcium enhances myocardial contractile force and exerts a vagomimetic effect that slows atrioventricular nodal conduction, aiding rate control in arrhythmias.

Side Effects

Metildigoxin may cause a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue

Serious or Rare Side Effects

  • Cardiac arrhythmias (including ventricular tachycardia)
  • Severe bradycardia
  • Visual disturbances (yellow‑green halos)

Precautions & Warnings

When prescribing Metildigoxin, clinicians should observe several precautionary measures to minimize toxicity.

  • Monitor serum electrolytes: especially potassium and magnesium levels should be kept within normal range.
  • Assess renal function: impaired clearance may require dose adjustment.
  • Check thyroid status: hypothyroidism can increase drug sensitivity.
  • Avoid use in patients with second‑degree or higher AV block without a pacemaker.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metildigoxin interacts with several medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid)

  • Amiodarone: markedly increases Metildigoxin serum levels, raising toxicity risk.
  • Quinidine: potentiates cardiac effects and can precipitate arrhythmias.
  • Verapamil: enhances drug effect and may lead to severe bradycardia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may cause hypokalemia, increasing toxicity potential.
  • NSAIDs: can reduce renal clearance and affect drug levels.

Frequently Asked Questions

Lanirapid contains Metildigoxin, a cardiac glycoside that is used to treat chronic heart failure and to control ventricular rate in atrial fibrillation. It may also be employed in certain supraventricular tachyarrhythmias where rate control or rhythm conversion is desired.

Metildigoxin inhibits the Na⁺/K⁺‑ATPase pump on cardiac cells, leading to increased intracellular sodium. This change reduces the activity of the sodium‑calcium exchanger, causing calcium to accumulate inside the cell, which strengthens myocardial contraction and slows atrioventricular nodal conduction.

The appropriate dose of Lanirapid is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, renal function, electrolyte status and response to therapy. No fixed dosing regimen is provided here.

Safety data for Metildigoxin during pregnancy and lactation are limited. It is generally avoided unless the potential benefit outweighs the risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Lanirapid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lanirapid (Metildigoxin) is chemically related to digoxin, the most widely used cardiac glycoside. Both share a similar mechanism of increasing intracellular calcium, but Metildigoxin may have a slightly different pharmacokinetic profile, potentially offering alternative dosing flexibility in certain patient populations.

Lanirapid tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Lanirapid is taken orally, usually with a glass of water. It may be taken with or without food, but consistency with respect to meals is recommended to maintain stable absorption. Patients should follow the prescriber’s instructions regarding timing and any required dose adjustments.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia, severe bradycardia, and visual disturbances like yellow‑green halos. Signs of toxicity—nausea, vomiting, confusion, or visual changes—should prompt immediate medical evaluation.

Lanirapid is contraindicated in patients with known hypersensitivity to Metildigoxin or other cardiac glycosides, those with uncontrolled ventricular arrhythmias, second‑degree or higher AV block without a pacemaker, and patients with severe renal impairment unless dose is carefully adjusted.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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