Product image of Lanitop (Metildigoxin) supplied by GNH India

Lanitop

Active Ingredient:
Metildigoxin
Origin:
EU

Lanitop (Metildigoxin)

Metildigoxin, the active ingredient in Lanitop, is a cardiac glycoside presented as an oral dosage form for oral use. It is employed in the management of congestive heart failure and certain atrial arrhythmias, improving cardiac contractility and controlling ventricular rate.

GNH India supplies Lanitop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides regulatory documentation for import.

Manufacturer / TM Owner

Esteve Pharmaceuticals Gmbh

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Indications & Clinical Uses

  • Metildigoxin is used in cardiac conditions that involve impaired contractility or abnormal atrial rhythm.
  • Congestive heart failure: enhances myocardial contractility, reducing symptoms such as dyspnea and edema.
  • Atrial fibrillation: slows atrioventricular nodal conduction, helping to control ventricular rate.
  • Atrial flutter: improves rate control by increasing AV nodal refractory period.

How It Works

  • Metildigoxin binds to the extracellular domain of the Na⁺/K⁺‑ATPase pump on cardiac myocytes, inhibiting its activity. This inhibition raises intracellular sodium, which reduces the activity of the sodium‑calcium exchanger, leading to an accumulation of intracellular calcium. The increased calcium availability enhances contractile force (positive inotropic effect) and prolongs atrioventricular nodal refractory period, thereby slowing conduction through the AV node.

Side Effects

Metildigoxin may be associated with a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Visual disturbances (e.g., blurred vision, yellow‑green tint)

Serious or Rare Side Effects

  • Cardiac arrhythmias (e.g., ventricular tachycardia)
  • Severe bradycardia
  • Hyperkalemia
  • Acute heart block

Precautions & Warnings

  • When prescribing Metildigoxin, clinicians should observe several safety measures to minimize risk.
  • Monitor serum electrolytes: check potassium and magnesium levels regularly to avoid toxicity.
  • Assess renal function: dose adjustments may be needed in impaired clearance.
  • Evaluate cardiac rhythm: baseline ECG is recommended before initiation.
  • Educate patients: advise on signs of toxicity such as visual changes or palpitations.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture.

Avoid Interactions

Metildigoxin interacts with several drug classes, requiring careful review of concomitant therapy.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: may increase risk of hyperkalemia and reduce drug efficacy.
  • Amiodarone: can potentiate digoxin‑like toxicity through pharmacokinetic inhibition.
  • Macrolide antibiotics (e.g., erythromycin): raise plasma concentrations, heightening toxicity risk.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: alter electrolyte balance, necessitating closer monitoring.
  • Beta‑blockers: additive effects on heart rate and AV nodal conduction.
  • ACE inhibitors: may enhance digoxin levels indirectly via renal effects.

Frequently Asked Questions

Lanitop contains Metildigoxin and is indicated for the management of congestive heart failure and for rate control in atrial fibrillation or atrial flutter. It helps improve cardiac output in heart failure and slows atrioventricular conduction in atrial arrhythmias.

Metildigoxin inhibits the Na⁺/K⁺‑ATPase pump on cardiac cells, leading to increased intracellular sodium. This change reduces calcium extrusion, raising intracellular calcium levels, which strengthens myocardial contraction and prolongs AV‑node refractory period, thereby slowing ventricular response in atrial tachyarrhythmias.

The appropriate dose of Lanitop is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, electrolyte status and therapeutic response. Dose titration is guided by clinical assessment and, when appropriate, serum drug concentration monitoring.

Safety data for Metildigoxin in pregnancy and lactation are limited. Because cardiac glycosides can cross the placenta and appear in breast milk, the drug is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant.

To request Lanitop, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative to Metildigoxin is digoxin, another cardiac glycoside. Both share a similar mechanism of action, but Metildigoxin may have a slightly different pharmacokinetic profile and potency. Choice between them depends on local regulatory status, clinician experience and individual patient response.

Lanitop tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Lanitop is taken orally, usually with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule provided by their healthcare professional.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia, severe bradycardia, and heart block. Signs of toxicity—such as visual disturbances, nausea, vomiting, or palpitations—should prompt immediate medical evaluation.

Lanitop is contraindicated in patients with known hypersensitivity to Metildigoxin, uncontrolled ventricular arrhythmias, severe sinus node dysfunction without a pacemaker, and in those with significant electrolyte disturbances (especially hyperkalemia) that have not been corrected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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