Product image of Lanitop (Metildigoxin) supplied by GNH India

Lanitop

Active Ingredient:
Metildigoxin
Origin:
EU

Lanitop (Metildigoxin)

Metildigoxin, the active ingredient in Lanitop, is a cardiac glycoside presented as an oral tablet for oral use. It is used to treat heart failure and control ventricular response in atrial fibrillation in adult patients.

GNH India supplies Lanitop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmakern Portugal – Produtos Farmacêuticos, Sociedade Unipessoal, Lda.

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Indications & Clinical Uses

Metildigoxin is employed in cardiovascular therapy to improve cardiac performance and rhythm control.

  • Heart failure: improves ventricular contractility and reduces symptoms of fluid overload.
  • Atrial fibrillation: helps control ventricular rate by slowing atrioventricular conduction.
  • Cardiac arrhythmias: stabilizes abnormal heart rhythms when other therapies are insufficient.

How It Works

  • Metildigoxin binds to the extracellular domain of the Na⁺/K⁺‑ATPase pump in myocardial cells, inhibiting its activity. This inhibition raises intracellular sodium, which indirectly increases calcium influx via the Na⁺/Ca²⁺ exchanger. Elevated intracellular calcium enhances contractile force (positive inotropy) while the drug also slows atrioventricular nodal conduction, producing a negative chronotropic effect that aids rate control.

Side Effects

Metildigoxin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Blurred vision
  • Fatigue

Serious or Rare Side Effects

  • Life‑threatening arrhythmias (e.g., ventricular tachycardia)
  • Severe bradycardia or heart block
  • Hyperkalemia
  • Allergic reactions such as skin rash or anaphylaxis

Precautions & Warnings

When prescribing Metildigoxin, clinicians should consider several safety precautions.

  • Renal impairment: monitor serum drug levels and renal function.
  • Electrolyte disturbances: avoid use in patients with hyperkalemia or hypomagnesemia.
  • Thyroid disease: use with caution in hyper‑ or hypothyroidism.
  • Elderly patients: start at lower doses due to increased sensitivity.
  • Concomitant medications: review all drugs for potential interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metildigoxin interacts with several medicines that can alter its concentration or cardiac effects.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: may precipitate hyperkalemia and toxicity.
  • Amiodarone: increases serum Metildigoxin levels, raising risk of toxicity.
  • Macrolide antibiotics (e.g., erythromycin): inhibit metabolism and elevate drug concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: additive negative chronotropic effect, may require dose adjustment.
  • ACE inhibitors: can enhance hypotensive response.
  • NSAIDs: may reduce renal clearance of Metildigoxin.

Frequently Asked Questions

Lanitop contains Metildigoxin and is prescribed to manage chronic heart failure and to control ventricular response in patients with atrial fibrillation. It helps improve cardiac output and stabilizes heart rhythm.

Metildigoxin inhibits the Na⁺/K⁺‑ATPase pump in heart muscle cells, leading to increased intracellular calcium. The higher calcium level strengthens heart contractions (positive inotropy) while the drug also slows conduction through the atrioventricular node, providing a negative chronotropic effect.

The dosage of Lanitop is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, renal function, electrolyte status, and response to therapy.

Safety of Metildigoxin in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Lanitop, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lanitop (Metildigoxin) belongs to the cardiac glycoside class, similar to digoxin. Both agents share the same mechanism of increasing intracellular calcium and slowing AV nodal conduction, but Metildigoxin may differ in potency, pharmacokinetic profile, and specific regulatory status in various regions.

Lanitop should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain stability.

Lanitop is administered orally, typically as a tablet taken with or without food as directed by the prescribing clinician. The exact timing and any dose adjustments are guided by therapeutic drug monitoring and clinical response.

The most serious risks include life‑threatening arrhythmias, severe bradycardia or heart block, and hyperkalemia. Patients should be monitored for signs of cardiac toxicity, visual disturbances, and electrolyte abnormalities.

Lanitop is contraindicated in patients with known hypersensitivity to Metildigoxin or other cardiac glycosides, in those with uncontrolled ventricular arrhythmias, and in individuals with severe electrolyte disturbances such as high potassium levels. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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