Lanoxin (Digoxin)

Digoxin inhibits the Na+/K+ ATPase pump in cardiac cells, leading to increased intracellular sodium. This change reduces the activity of the Na+/Ca2+ exchanger, causing a rise in intracellular calcium that strengthens myocardial contraction. Additionally, digoxin enhances vagal tone, slowing conduction through the atrioventricular node and helping to control heart rate.

The dose of digoxin is individualized. A prescriber determines the appropriate strength and schedule based on factors such as the patient’s age, renal function, body weight, and clinical response. Dose adjustments are common, especially in patients with renal impairment or when interacting medications are present.

Digoxin is classified as pregnancy category C, meaning risk cannot be ruled out. It should be used only if the potential benefit justifies the potential risk to the fetus. Limited data exist for breastfeeding; caution is advised and a healthcare professional should evaluate the risk‑benefit ratio before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Digoxin offers a unique mechanism by directly increasing cardiac contractility and providing rate control, unlike ACE inhibitors, beta‑blockers, or diuretics that act on neuro‑hormonal pathways. Contemporary guidelines often reserve digoxin for patients who remain symptomatic despite optimal standard therapy, making it a complementary option rather than a first‑line agent.

Store Lanoxin at ambient temperature below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Do not refrigerate or freeze the tablets, and keep the container tightly closed to maintain product stability.

Lanoxin is taken orally as a tablet, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water; crushing or chewing is not recommended unless specifically instructed by a healthcare professional.

The most critical risks include cardiac arrhythmias such as ventricular tachycardia, severe bradycardia, or heart block, especially when serum digoxin levels become elevated. Other serious concerns are hyperkalemia, visual disturbances like yellow‑green halos, and allergic reactions. Immediate medical attention is required if any of these occur.

Lanoxin is contraindicated in individuals with known hypersensitivity to digoxin, uncontrolled ventricular arrhythmias, high‑grade AV block without a functioning pacemaker, and severe electrolyte disturbances, particularly hyperkalemia. Caution is also advised in patients with significant renal impairment.