Product image of Lanoxin Injectie (Digoxin) supplied by GNH India

Lanoxin Injectie

Active Ingredient:
Digoxin
Origin:
EU

Lanoxin Injectie (Digoxin)

Digoxin, the active ingredient in Lanoxin Injectie, is a cardiac glycoside presented as an injectable solution for intravenous use. It is employed in the management of heart failure and atrial fibrillation, improving cardiac contractility and controlling ventricular rate in adult patients with these conditions.

GNH India supplies Lanoxin Injectie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved documentation for each shipment.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

  • Digoxin is a cardiac glycoside used in the management of cardiac conditions that affect heart contractility and rhythm.
  • Heart failure: improves cardiac contractility and reduces symptoms of fatigue and dyspnea.
  • Atrial fibrillation: slows ventricular response and may aid in rhythm control.
  • Cardiac arrhythmias: provides rate control in certain supraventricular tachyarrhythmias.

How It Works

  • Digoxin inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocytes, leading to an increase in intracellular sodium. The elevated sodium reduces the activity of the Na⁺/Ca²⁺ exchanger, causing intracellular calcium accumulation. This calcium boost enhances myocardial contractility (positive inotropic effect) and also increases vagal tone, slowing atrioventricular nodal conduction.

Side Effects

Digoxin may cause a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Dizziness
  • Blurred vision (yellow/green halos)

Serious or Rare Side Effects

  • Cardiac arrhythmias
  • Severe bradycardia
  • Heart block
  • Hyperkalemia
  • Visual disturbances (scotoma)
  • Allergic reactions (anaphylaxis)

Precautions & Warnings

  • When using digoxin, several safety considerations are essential.
  • Renal function: adjust use in patients with impaired renal clearance.
  • Electrolyte balance: monitor potassium and magnesium levels closely.
  • Thyroid disease: use cautiously in hyperthyroid patients.
  • Concomitant drugs: avoid medications that markedly alter digoxin concentrations.
  • Pregnancy: category C, weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Digoxin interacts with a variety of medicines that can affect its plasma concentration or pharmacodynamic response.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin serum concentrations.
  • Quinidine: raises digoxin levels.
  • Verapamil: enhances digoxin effect and toxicity risk.
  • Spironolactone: may increase digoxin concentrations.
  • Macrolide antibiotics (e.g., erythromycin): elevate digoxin levels.

Moderate Interactions (Monitor Closely)

  • Diuretics (loop, thiazide): cause electrolyte shifts influencing digoxin toxicity.
  • Beta‑blockers: additive effect on heart rate.
  • ACE inhibitors: may alter renal function affecting digoxin clearance.
  • Antacids containing aluminum or magnesium: reduce digoxin absorption.
  • Antidepressants (SSRIs): potential modest increase in digoxin levels.

Frequently Asked Questions

Lanoxin Injectie is an intravenous formulation of digoxin, a cardiac glycoside indicated for the treatment of heart failure and for rate control in atrial fibrillation. It helps improve cardiac contractility and can stabilize ventricular response in patients with these conditions.

Digoxin works by inhibiting the Na⁺/K⁺‑ATPase pump on heart muscle cells, which raises intracellular sodium. This change reduces the Na⁺/Ca²⁺ exchange, leading to higher intracellular calcium levels that strengthen heart contractions. It also increases vagal tone, slowing conduction through the atrioventricular node.

The appropriate dose of Lanoxin Injectie is individualized by the prescribing clinician based on factors such as the patient’s age, renal function, electrolyte status, and severity of the cardiac condition. No fixed regimen is provided here; dosing decisions are made by qualified healthcare professionals.

Digoxin is classified as Pregnancy Category C, meaning risk cannot be ruled out. It may be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding, so clinicians should evaluate the risk‑benefit ratio before use.

To order Lanoxin Injectie, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Lanoxin Injectie (digoxin) provides a positive inotropic effect and rate control, whereas agents such as milrinone act via phosphodiesterase inhibition and primarily increase contractility without significant AV‑node effects. Digoxin has a narrow therapeutic window and requires careful monitoring, while some newer inotropes may have broader safety margins but different side‑effect profiles.

Lanoxin Injectie should be stored at 2‑8 °C in a refrigerator, protected from light. The vial must not be frozen or shaken vigorously. Keep the product in its original packaging until use to maintain stability and potency.

The medication is given by intravenous injection or infusion under the supervision of a qualified healthcare professional. Dosage and rate of administration are determined by the prescriber, and the solution should be administered using aseptic technique to avoid contamination.

The most critical risks include digoxin toxicity, which can manifest as life‑threatening cardiac arrhythmias, severe bradycardia, heart block, and hyperkalemia. Visual disturbances such as blurred or colored vision may also signal toxicity and require immediate medical evaluation.

Lanoxin Injectie is contraindicated in patients with known hypersensitivity to digoxin or other cardiac glycosides, in those with uncontrolled ventricular arrhythmias, and in individuals with severe renal impairment where drug clearance is markedly reduced. Caution is also advised for patients with electrolyte imbalances such as hypokalemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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