Product image of Lanoxin Pg (Digoxin) supplied by GNH India

Lanoxin Pg

Active Ingredient:
Digoxin
Origin:
EU

Lanoxin Pg (Digoxin)

Digoxin, the active ingredient in Lanoxin Pg, is a cardiac glycoside presented as an oral tablet for oral use. It is employed in the management of certain heart conditions, notably heart failure and atrial fibrillation, to improve cardiac contractility and control ventricular rate. It is commonly prescribed under careful medical supervision.

GNH India supplies Lanoxin Pg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Digoxin acts on the cardiac conduction system and myocardial contractility, making it useful in specific cardiovascular conditions.

  • Heart failure: improves symptoms, exercise tolerance and may reduce hospitalizations.
  • Atrial fibrillation: helps control ventricular rate and can improve functional capacity.
  • Atrial flutter: assists in ventricular rate control during rapid atrial response.

How It Works

  • Digoxin binds to and inhibits the Na+/K+ ATPase pump on cardiac myocyte membranes, leading to an increase in intracellular sodium. This alteration reduces the activity of the sodium‑calcium exchanger, causing calcium accumulation inside the cells, which enhances myocardial contractility. Additionally, digoxin exerts vagomimetic effects that slow atrioventricular nodal conduction, aiding rate control in atrial arrhythmias.

Side Effects

Digoxin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Blurred vision
  • Headache

Serious or Rare Side Effects

  • Cardiac arrhythmias
  • Severe bradycardia
  • Heart block
  • Hyperkalemia
  • Anaphylactic reaction
  • Color vision disturbances (e.g., yellow‑green halos)

Precautions & Warnings

When using digoxin, clinicians should observe several safety measures to minimize risk.

  • Monitor serum digoxin level: adjust dose based on therapeutic range.
  • Assess renal function: dose may need reduction in impairment.
  • Check electrolytes, especially potassium: hypokalemia increases toxicity risk.
  • Use caution in elderly patients: increased sensitivity to effects.
  • Avoid overdose: follow prescribing instructions precisely.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Digoxin interacts with several medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin levels, raising toxicity risk.
  • Quinidine: raises digoxin concentration and may precipitate arrhythmias.
  • Verapamil: enhances digoxin effect and risk of bradycardia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics (e.g., furosemide): may cause electrolyte shifts affecting digoxin.
  • ACE inhibitors (e.g., enalapril): can increase digoxin levels.
  • Beta‑blockers (e.g., metoprolol): additive slowing of heart rate.
  • NSAIDs (e.g., ibuprofen): may reduce renal clearance of digoxin.

Frequently Asked Questions

Lanoxin Pg contains digoxin, which is prescribed to treat heart failure and to control ventricular rate in atrial fibrillation or atrial flutter. It helps improve cardiac output and stabilises heart rhythm in these specific cardiovascular conditions.

Digoxin inhibits the Na+/K+ ATPase pump in heart muscle cells, leading to increased intracellular calcium. This boost in calcium enhances the strength of cardiac contractions, while its vagomimetic action slows conduction through the atrioventricular node, helping to control heart rate.

The appropriate dose of Lanoxin Pg is individualized by the prescribing clinician based on factors such as the patient’s age, kidney function, electrolyte status, and therapeutic drug‑monitoring results. No fixed regimen is provided here; the prescriber sets the dose.

Safety data for digoxin in pregnancy and lactation are limited. It is generally used only when the potential benefit outweighs potential risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Lanoxin Pg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Unlike ACE inhibitors or beta‑blockers, digoxin primarily increases contractile force and provides rate‑control benefits in atrial arrhythmias. It is often added to standard therapy when additional symptom relief is needed, but it requires careful monitoring for toxicity, which is less of a concern with many other agents.

Store Lanoxin Pg at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Lanoxin Pg is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

The most critical risks include cardiac arrhythmias, severe bradycardia, heart block, and hyperkalemia, all of which can be life‑threatening. Prompt medical attention is required if patients experience palpitations, fainting, visual disturbances, or signs of toxicity.

Lanoxin Pg should be avoided in patients with known hypersensitivity to digoxin, uncontrolled ventricular arrhythmias, severe conduction disturbances without a pacemaker, and in those with significant renal impairment unless dose is appropriately adjusted and closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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