Product image of Lanoxin Pg (Digoxin) supplied by GNH India

Lanoxin Pg

Active Ingredient:
Digoxin
Origin:
EU

Lanoxin Pg (Digoxin)

Digoxin, the active ingredient in Lanoxin Pg, is a cardiac glycoside presented as an oral tablet for oral use. It treats heart failure and atrial fibrillation in adult patients.
GNH India supplies Lanoxin Pg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Lanoxin Pg (digoxin) is used in cardiovascular conditions that involve impaired contractility or abnormal rhythm control.

  • Heart failure: improves cardiac output and reduces symptoms of fluid overload.
  • Atrial fibrillation: slows atrioventricular nodal conduction to control ventricular rate.

How It Works

  • Digoxin binds to and inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocytes, leading to an increase in intracellular sodium. This reduces the activity of the sodium‑calcium exchanger, causing calcium accumulation inside the cells, which enhances myocardial contractility. In the conduction system, the drug prolongs the refractory period of the AV node, thereby slowing ventricular response in atrial arrhythmias.

Side Effects

Digoxin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Vomiting: occasional emesis, especially after dose initiation.
  • Diarrhea: loose stools without blood.
  • Fatigue: generalized tiredness.
  • Blurred vision: transient visual disturbances.
  • Headache: mild cranial discomfort.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Severe bradycardia: markedly slowed heart rate.
  • Heart block: impaired electrical conduction.
  • Hyperkalemia: elevated serum potassium levels.
  • Allergic skin reactions: rash or urticaria.
  • Visual halos: yellow‑green colored visual disturbances.

Precautions & Warnings

When prescribing digoxin, clinicians should consider several safety measures to minimize toxicity.

  • Renal impairment: adjust dose and monitor serum levels.
  • Electrolyte balance: correct hypokalemia, hypomagnesemia, and hypercalcemia before therapy.
  • Elderly patients: start with lower doses and assess tolerance.
  • Concomitant arrhythmias: avoid use in patients with ventricular tachyarrhythmias.
  • Drug monitoring: obtain periodic digoxin serum concentrations.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Digoxin interacts with several medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin levels, raising toxicity risk.
  • Quinidine: elevates serum digoxin concentrations.
  • Verapamil: potentiates digoxin effects and may cause bradyarrhythmias.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: cause hypokalemia, enhancing digoxin toxicity.
  • NSAIDs: may reduce renal clearance, necessitating serum level checks.

Frequently Asked Questions

Lanoxin Pg contains digoxin, which is prescribed for patients with chronic heart failure to improve cardiac output and for atrial fibrillation to control ventricular rate by slowing atrioventricular nodal conduction.

Digoxin inhibits the Na⁺/K⁺‑ATPase pump in heart muscle cells, leading to increased intracellular calcium. This enhances the strength of each heartbeat and prolongs the refractory period of the AV node, helping to regulate abnormal heart rhythms.

The appropriate dose of digoxin is individualized. A qualified prescriber determines the exact amount based on the patient’s age, renal function, electrolyte status, and clinical response, and then provides specific dosing instructions.

Digoxin is classified as a pregnancy‑category C medication, meaning risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding, so a healthcare professional should evaluate safety on a case‑by‑case basis.

To place an order, submit an enquiry on the Lanoxin Pg product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Digoxin is a cardiac glycoside that primarily increases contractility and controls rate, whereas other classes such as ACE inhibitors, beta‑blockers, and ARBs act mainly on neuro‑hormonal pathways. Digoxin is often added when symptoms persist despite optimal therapy with those agents.

Lanoxin Pg should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lanoxin Pg is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia or severe bradycardia, heart block, and digoxin toxicity manifested by nausea, visual disturbances, and electrolyte imbalances. Prompt medical attention is required if these symptoms appear.

Lanoxin Pg is contraindicated in patients with ventricular fibrillation, ventricular tachycardia, advanced atrioventricular block without a pacemaker, and those with known hypersensitivity to digoxin or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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