Product image of Lanoxin Pg (Digoxin) supplied by GNH India

Lanoxin Pg

Active Ingredient:
Digoxin
Origin:
EU

Lanoxin Pg (Digoxin)

Digoxin, the active ingredient in Lanoxin Pg, is a cardiac glycoside presented as an oral tablet for systemic use. It improves cardiac contractility and helps control ventricular response in patients with heart failure and certain atrial arrhythmias by influencing ion transport in heart muscle cells. GNH India supplies Lanoxin Pg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Digoxin is a cardiac glycoside used in the management of cardiovascular conditions that affect heart contractility and rhythm.

  • Heart failure: improves cardiac output and reduces symptoms of fluid overload.
  • Atrial fibrillation: slows ventricular rate by enhancing AV nodal conduction delay.
  • Atrial flutter: helps control ventricular response and may aid in rhythm conversion.

How It Works

  • Digoxin binds to and inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocyte membranes, increasing intracellular sodium. The elevated sodium reduces activity of the sodium‑calcium exchanger, leading to calcium accumulation inside the cell, which enhances myocardial contractility (positive inotropic effect). Additionally, digoxin augments vagal tone, slowing atrioventricular nodal conduction and reducing heart rate.

Side Effects

Digoxin may cause a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Vomiting: occasional emesis.
  • Diarrhea: loose stools.
  • Fatigue: generalized tiredness.
  • Visual disturbances: blurred or yellow‑green vision.
  • Headache: mild cranial pain.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially fatal rhythm disturbances.
  • Severe bradycardia: markedly slowed heart rate.
  • Hyperkalemia: elevated blood potassium levels.
  • Pulmonary edema: fluid accumulation in lungs.
  • Anaphylactic reaction: rare hypersensitivity.

Precautions & Warnings

When prescribing digoxin, clinicians should consider several safety measures to minimize risk.

  • Renal function: adjust dose in patients with impaired clearance.
  • Electrolyte balance: monitor potassium and magnesium levels.
  • Drug level monitoring: obtain serum digoxin concentration as indicated.
  • Concomitant medications: review for agents that affect digoxin metabolism or increase toxicity.
  • Pregnancy and lactation: use only if benefit outweighs potential risk.
  • Store at ambient temperature: keep below 25 °C, in original container, protected from moisture and light.

Avoid Interactions

Digoxin interacts with several medicines that can alter its concentration or cardiac effects.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin levels, risk of toxicity.
  • Quinidine: raises serum digoxin, may cause arrhythmias.
  • Verapamil: enhances digoxin effect, leading to bradycardia.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., furosemide, thiazides): may cause electrolyte disturbances that predispose to toxicity.
  • ACE inhibitors and ARBs: can increase digoxin levels modestly.
  • Beta‑blockers: additive effect on heart rate and AV conduction.

Frequently Asked Questions

Lanoxin Pg contains digoxin, which is prescribed to improve heart muscle contraction in chronic heart failure and to control the ventricular rate in atrial fibrillation or atrial flutter. By enhancing cardiac output and slowing abnormal electrical conduction, it helps reduce symptoms such as shortness of breath, fatigue, and palpitations.

Digoxin inhibits the Na⁺/K⁺‑ATPase pump on cardiac cells, causing an increase in intracellular sodium. This change reduces the activity of the sodium‑calcium exchanger, leading to higher calcium levels inside the heart muscle, which strengthens each contraction. It also increases vagal tone, slowing conduction through the atrioventricular node and reducing heart rate.

The appropriate dose of Lanoxin Pg is individualized and must be determined by a qualified prescriber. Dosage depends on factors such as the patient’s age, renal function, electrolyte status, and response to therapy. Physicians typically start with a low dose and adjust based on clinical response and serum digoxin levels.

Safety data for digoxin in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the Lanoxin Pg product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Digoxin belongs to the cardiac glycoside class and primarily provides a positive inotropic effect and rate control, whereas many modern heart‑failure drugs (e.g., ACE inhibitors, beta‑blockers, ARNI) act by neurohormonal modulation. Digoxin is often added when patients remain symptomatic despite guideline‑directed therapy, but it requires careful monitoring for toxicity, unlike many newer agents.

Lanoxin Pg tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources, and discard any tablets that appear discolored or damaged.

Lanoxin Pg is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water. Patients should follow the exact dosing schedule provided and avoid crushing or chewing the tablet unless specifically instructed by a healthcare professional.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia or severe bradycardia, which can be life‑threatening. Other critical concerns are hyperkalemia, especially in patients with renal impairment, and signs of digoxin toxicity like nausea, visual changes (yellow‑green halos), and confusion. Prompt medical attention is required if any of these symptoms occur.

Lanoxin Pg should be avoided in patients with known hypersensitivity to digoxin or other cardiac glycosides, in those with uncontrolled ventricular arrhythmias, and in individuals with severe renal failure without dose adjustment. Caution is also advised for patients taking interacting medications such as amiodarone or quinidine, and for pregnant or breastfeeding women unless the benefit clearly outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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