Product image of Lanreotid Amdipharm (Lanreotide Acetate) supplied by GNH India

Lanreotid Amdipharm

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Lanreotid Amdipharm (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Lanreotid Amdipharm, is a somatostatin analog presented as a subcutaneous formulation for subcutaneous use. It is employed to lower excess growth hormone in adults with acromegaly and to control hormone‑secreting neuroendocrine tumors.

GNH India supplies Lanreotid Amdipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The product meets European Union quality standards and is distributed under strict temperature‑controlled conditions. Our global logistics network ensures timely delivery to clinical sites across continents, supporting patient access to specialized therapies.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Lanreotide acetate is a somatostatin analog used in conditions driven by excess hormone secretion.

  • Acromegaly: reduces serum growth hormone and IGF‑1 levels, helping control disease activity in adults.
  • Gastroenteropancreatic neuroendocrine tumors: suppresses hormone secretion and can stabilize tumor growth in patients with functional NETs.
  • Carcinoid syndrome: alleviates flushing and diarrhea associated with hormone‑producing tumors.

How It Works

  • Lanreotide acetate is a synthetic analogue of the natural hormone somatostatin. After subcutaneous injection it binds with high affinity to somatostatin receptor subtypes 2 and 5 on pituitary and neuroendocrine cells. This binding inhibits adenylate cyclase activity, reduces cyclic AMP formation and blocks calcium‑dependent exocytosis, leading to decreased secretion of growth hormone, insulin‑like growth factor‑1, and various peptide hormones produced by neuroendocrine tumors.

Side Effects

Lanreotide acetate may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Injection site pain or erythema
  • Diarrhea
  • Nausea
  • Abdominal discomfort
  • Headache
  • Flushing

Serious or Rare Side Effects

  • Gallbladder sludge or gallstones
  • Hyperglycemia or new‑onset diabetes
  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Cardiac arrhythmias
  • Severe hepatic dysfunction

Precautions & Warnings

Before initiating lanreotide therapy, several safety considerations should be reviewed.

  • Glucose monitoring: assess blood sugar levels as treatment may worsen hyperglycemia.
  • Gallbladder evaluation: screen for gallstones or biliary disease before use.
  • Cardiac assessment: monitor for arrhythmias in patients with known heart conduction issues.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks; discuss with obstetric specialist.
  • Renal/hepatic function: adjust therapy in patients with significant impairment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide can interact with other medicines, affecting its efficacy or safety profile.

Major Interactions (Avoid)

  • Cytochrome P450 inhibitors (e.g., ketoconazole): may increase lanreotide plasma concentrations.
  • Co‑administration with other somatostatin analogues: additive hormonal suppression can lead to severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: monitor glucose as lanreotide may alter glycemic control.
  • Anticoagulants (e.g., warfarin): observe INR values for potential changes.
  • Diuretics: watch electrolyte balance, especially potassium.
  • Thyroid hormone replacement: assess thyroid function tests periodically.

Frequently Asked Questions

Lanreotid Amdipharm contains lanreotide acetate, a somatostatin analogue indicated for the medical management of adult acromegaly and for controlling hormone‑secreting gastroenteropancreatic neuroendocrine tumours. By suppressing excess growth hormone and various peptide hormones, it helps reduce disease‑related symptoms and biochemical abnormalities.

Lanreotide acetate mimics the natural hormone somatostatin and binds preferentially to somatostatin receptor subtypes 2 and 5 on pituitary and neuroendocrine cells. This interaction inhibits adenylate cyclase, lowers cyclic AMP, and blocks calcium‑mediated secretion, resulting in reduced release of growth hormone, IGF‑1, and other tumor‑derived peptides.

The dosing regimen for Lanreotid Amdipharm is individualized by the prescribing physician based on the patient’s clinical condition, disease severity, and response to therapy. The prescriber determines the appropriate injection volume, frequency, and any necessary adjustments during treatment.

Safety data for lanreotide acetate in pregnancy and lactation are limited. The product should be used only if the potential benefit to the mother outweighs possible risks to the fetus or infant, and treatment decisions should involve a qualified obstetric or neonatal specialist.

To request Lanreotid Amdipharm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Lanreotid Amdipharm (lanreotide) and other agents such as octreotide share a similar mechanism of binding somatostatin receptors, but they differ in dosing frequency, formulation, and pharmacokinetic profile. Lanreotide is often administered as a long‑acting depot injection, allowing less frequent dosing compared with short‑acting octreotide formulations.

Lanreotid Amdipharm should be stored in a refrigerator at 2 °C to 8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. If temporary storage at room temperature is unavoidable, limit exposure to no more than 30 minutes.

The medication is supplied for subcutaneous injection. A healthcare professional prepares the dose according to the prescriber’s instructions and administers it into the subcutaneous tissue, typically in the abdomen or thigh. Patients should be trained on proper injection technique and site rotation to minimise local reactions.

Serious adverse events, although uncommon, include gallbladder disease (gallstones or sludge), hyperglycaemia or new‑onset diabetes, acute pancreatitis, severe allergic reactions such as anaphylaxis, and cardiac arrhythmias. Prompt medical evaluation is required if any of these symptoms develop during therapy.

Lanreotid Amdipharm is contraindicated in patients with known hypersensitivity to lanreotide acetate or any excipients in the formulation. Caution is also advised for individuals with severe uncontrolled diabetes, active gallbladder disease, or significant cardiac conduction abnormalities, and it should be avoided in pregnancy unless clearly justified.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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