Product image of Lanreotid Zentiva (Lanreotide) supplied by GNH India

Lanreotid Zentiva

Active Ingredient:
Lanreotide
Origin:
EU

Lanreotid Zentiva (Lanreotide)

Lanreotide, the active ingredient in Lanreotid Zentiva, is a somatostatin analog presented as an injectable solution for subcutaneous use. It reduces excess growth hormone in acromegaly and controls hormone‑secreting neuroendocrine tumors in adult patients.

GNH India supplies Lanreotid Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to EU GMP standards and provides cold‑chain logistics to ensure product integrity during global distribution. Clients benefit from reliable supply, technical support and regulatory documentation.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Lanreotide is used in endocrine disorders that involve excess hormone secretion.
  • Acromegaly: reduces growth hormone secretion, normalizes IGF‑1 levels and improves clinical symptoms such as enlarged hands, facial features and joint pain.
  • Neuroendocrine tumors: controls hormone secretion from functional tumors, alleviating carcinoid syndrome symptoms like flushing and diarrhea and may slow tumor progression.
  • Carcinoid syndrome: specifically reduces flushing, bronchospasm and diarrhoea associated with serotonin‑producing neuroendocrine tumors.
  • Functional pancreatic neuroendocrine tumors: decreases excessive hormone output, aiding control of symptoms such as hypoglycemia or gastric hypersecretion.

How It Works

  • Lanreotide is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes sst2 and sst5 on endocrine cells. Activation of these G‑protein‑coupled receptors inhibits adenylate cyclase activity, reducing cyclic AMP formation and downstream calcium influx. This suppresses the secretion of growth hormone, insulin, glucagon and various peptide hormones released by neuroendocrine tumors, thereby lowering circulating hormone levels and mitigating disease‑related effects.

Side Effects

Lanreotide may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Injection site reactions: pain, erythema, induration or swelling at the injection site.
  • Gastrointestinal disturbances: nausea, abdominal pain, diarrhea or constipation.
  • Gallbladder abnormalities: biliary sludge, gallstones or cholecystitis.
  • Hyperglycemia: elevated fasting glucose or HbA1c levels.

Serious or Rare Side Effects

  • Pancreatitis: severe abdominal pain with raised pancreatic enzymes.
  • Severe allergic reactions: anaphylaxis, urticaria, angioedema or bronchospasm.
  • Cardiac conduction disturbances: bradycardia, heart block or other arrhythmias.

Precautions & Warnings

When prescribing Lanreotide, clinicians should consider several precautionary measures to ensure safe use.

  • Assess baseline hormone levels: evaluate growth hormone and IGF‑1 before initiating therapy.
  • Monitor glucose metabolism: check fasting glucose and HbA1c periodically during treatment.
  • Evaluate gallbladder status: perform ultrasound in patients with a history of gallstones or biliary disease.
  • Review concomitant medications: avoid drugs that may exacerbate hyperglycemia or affect gastrointestinal motility.
  • Adjust in organ impairment: use caution and consider dose modification in severe renal or hepatic dysfunction.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Cyclosporine: may increase lanreotide plasma concentrations, raising risk of adverse effects.
  • Somatostatin analog antagonists: can diminish the therapeutic effect of lanreotide.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemic agents: lanreotide may affect glucose control, requiring dose adjustments.
  • Insulin therapy: monitor blood glucose closely as lanreotide can alter insulin requirements.
  • Medications that prolong QT interval: co‑administration may increase risk of cardiac arrhythmias.
  • Octreotide: concurrent use may lead to additive hormonal suppression.

Frequently Asked Questions

Lanreotid Zentiva contains the somatostatin analogue lanreotide and is indicated for the treatment of adult patients with acromegaly, a condition of excess growth hormone, and for the control of hormone‑secreting neuroendocrine tumors, including carcinoid syndrome. It helps lower hormone levels and manage disease‑related symptoms.

Lanreotide mimics natural somatostatin and binds preferentially to somatostatin receptor subtypes sst2 and sst5 on endocrine and neuroendocrine cells. Receptor activation inhibits adenylate cyclase, reduces cyclic AMP and calcium influx, and consequently suppresses the secretion of growth hormone, insulin, glucagon and other peptide hormones, leading to clinical benefit in the targeted disorders.

The specific dose and dosing interval of Lanreotid Zentiva are determined by the prescribing physician based on the patient’s condition, disease severity, and response to therapy. Lanreotide is typically administered as a subcutaneous injection at intervals ranging from four weeks to longer, but exact regimens must be individualized and follow the approved product labeling.

The safety of lanreotide during pregnancy and lactation has not been fully established. Animal studies have shown adverse effects on fetal development, and there are limited human data. Consequently, lanreotide should be used only if the potential benefit justifies the potential risk to the fetus or infant, and breastfeeding mothers should discuss alternatives with their healthcare provider.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides a quotation, availability details, shipping options—including cold‑chain logistics where required—and assistance with import documentation.

The primary alternative to lanreotide is octreotide, another somatostatin analogue. Both agents bind to sst2 receptors and suppress hormone secretion, but lanreotide has a longer half‑life, allowing dosing every four weeks, whereas octreotide often requires more frequent administration. Clinical efficacy is comparable for acromegaly and neuroendocrine tumor control, while individual tolerability and injection‑site reactions may differ.

Lanreotid Zentiva must be stored in a refrigerator at 2‑8 °C (36‑46 °F). The product should be kept in its original packaging to protect it from light, should not be frozen, and must not be shaken. If temporary storage at room temperature is unavoidable, limit exposure to less than 24 hours and return the product to refrigerated conditions promptly.

Lanreotid Zentiva is supplied as an injectable solution for subcutaneous injection. A healthcare professional prepares the dose using aseptic technique, selects an appropriate injection site (typically the abdomen or thigh), and administers the medication into the subcutaneous tissue. Patients may be taught self‑injection after proper training, and the injection interval is usually every four weeks, as prescribed.

The most serious adverse events associated with lanreotide include pancreatitis, severe allergic reactions such as anaphylaxis, and cardiac conduction disturbances like bradycardia or heart block. Patients should be instructed to seek immediate medical attention if they experience intense abdominal pain, signs of an allergic reaction (e.g., swelling, difficulty breathing), or unexplained faintness, palpitations, or syncope.

Lanreotide is contraindicated in patients with known hypersensitivity to lanreotide or any of the excipients in the formulation. Caution is advised in individuals with severe hepatic impairment, uncontrolled diabetes, or active gallbladder disease, as the drug may exacerbate these conditions. Pregnant or breastfeeding women should only use it when the potential benefit outweighs the risk, and it should be avoided in patients with a history of severe pancreatitis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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