Product image of Lanreotid Zentiva (Lanreotide) supplied by GNH India

Lanreotid Zentiva

Active Ingredient:
Lanreotide
Origin:
EU

Lanreotid Zentiva (Lanreotide)

Lanreotide, the active ingredient in Lanreotid Zentiva, is a somatostatin analog presented as a subcutaneous formulation for subcutaneous use. It is employed to treat acromegaly and neuroendocrine tumors in adult patients.
GNH India supplies Lanreotid Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Lanreotid Zentiva is a somatostatin analog used in endocrine disorders and neuroendocrine tumor management.
  • Acromegaly: reduces growth hormone and IGF‑1 levels to control disease activity.
  • Neuroendocrine tumors (e.g., carcinoid tumors): suppresses tumor‑related hormone secretion and stabilises disease.
  • Prevention of recurrence of acromegaly after surgery: maintains hormonal control post‑operatively.

How It Works

  • Lanreotide binds with high affinity to somatostatin receptors SSTR2 and SSTR5 on target cells. This interaction inhibits adenylate cyclase activity, reducing cyclic AMP formation and subsequently decreasing secretion of growth hormone, insulin‑like growth factor‑1, and various gastrointestinal hormones, leading to clinical control of hormone‑dependent conditions.

Side Effects

Lanreotid Zentiva may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Injection site pain or erythema
  • Abdominal discomfort or cramps
  • Diarrhoea
  • Nausea
  • Headache
  • Flushing

Serious or Rare Side Effects

  • Gallstone formation or biliary sludge
  • Hyperglycaemia or new‑onset diabetes mellitus
  • Pancreatitis or elevated pancreatic enzymes
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Cardiac arrhythmias or conduction abnormalities

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for potential complications.

  • Monitor blood glucose: patients may develop hyperglycaemia.
  • Assess gallbladder health: risk of gallstone formation.
  • Check for hypersensitivity: avoid in patients with known allergy to lanreotide.
  • Use caution in cardiac disease: monitor ECG if arrhythmias are a concern.
  • Adjust in hepatic or renal impairment as clinically indicated.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotid Zentiva can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with cyclosporine: may increase lanreotide plasma levels.
  • Co‑administration with other somatostatin analogs: additive hormonal suppression.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: blood glucose may rise, requiring dose adjustment.
  • CYP450 substrates (e.g., midazolam): potential alteration of metabolism.
  • QT‑prolonging drugs: monitor cardiac rhythm for additive effects.

Frequently Asked Questions

Lanreotid Zentiva is prescribed for adult patients with acromegaly, for control of hormone secretion in neuroendocrine tumors such as carcinoid tumors, and to prevent recurrence of acromegaly after surgical treatment. It works by targeting the hormonal pathways that drive these diseases.

Lanreotide is a synthetic analogue of somatostatin. It binds to somatostatin receptors SSTR2 and SSTR5 on pituitary and tumor cells, inhibiting adenylate cyclase, reducing cyclic AMP, and consequently decreasing the release of growth hormone, IGF‑1, and various gastrointestinal hormones that contribute to disease activity.

The specific dose and dosing interval of Lanreotid Zentiva are determined by the prescribing physician based on the individual patient's condition, response to therapy, and clinical guidelines. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lanreotide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Lanreotid Zentiva (lanreotide) and other agents such as octreotide share a similar mechanism of binding somatostatin receptors, but they differ in formulation, dosing frequency, and pharmacokinetic profiles. Lanreotide is often administered as a long‑acting injectable, allowing less frequent dosing compared with some short‑acting alternatives.

Lanreotid Zentiva should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and potency.

The medication is given by subcutaneous injection, typically performed by a healthcare professional. The injection site is rotated to minimise local irritation, and the preparation is used immediately after removal from refrigeration, following aseptic technique.

Serious adverse events, though uncommon, include gallstone formation, significant hyperglycaemia or new‑onset diabetes, pancreatitis, severe allergic reactions such as anaphylaxis, and cardiac arrhythmias. Patients should be monitored regularly for these conditions, and any concerning symptoms reported promptly.

Lanreotid Zentiva is contraindicated in patients with known hypersensitivity to lanreotide or any of its excipients. Caution is advised for individuals with severe hepatic or renal impairment, uncontrolled diabetes, active gallbladder disease, or significant cardiac conduction abnormalities, and it should be avoided unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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