Product image of Lanreotide Zentiva (Lanreotide) supplied by GNH India

Lanreotide Zentiva

Active Ingredient:
Lanreotide
Origin:
EU

Lanreotide Zentiva (Lanreotide)

Lanreotide, the active ingredient in Lanreotide Zentiva, is a somatostatin analog presented as a subcutaneous formulation for injection use. It treats acromegaly and neuroendocrine tumors in adult patients.
GNH India supplies Lanreotide Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Lanreotide is a somatostatin analog used in endocrine disorders that involve excess hormone secretion.

  • Acromegaly: normalises elevated growth hormone levels and reduces associated tissue overgrowth.
  • Neuroendocrine tumors: controls hormone‑related symptoms and can slow tumor progression.
  • Carcinoid syndrome: alleviates flushing, diarrhoea and other secretory manifestations linked to functional neuroendocrine tumours.

How It Works

  • Lanreotide is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes (SSTR2, SSTR5). Receptor activation inhibits adenylate cyclase, reduces intracellular cAMP and suppresses the secretion of growth hormone, insulin‑like growth factor‑1 and various peptide hormones, thereby controlling tumour‑related hormone excess and growth‑hormone driven disease.

Side Effects

Lanreotide may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Injection site pain or erythema
  • Nausea or abdominal discomfort
  • Diarrhoea or constipation
  • Headache
  • Hyperglycaemia or altered glucose tolerance
  • Gallstone formation

Serious or Rare Side Effects

  • Acute pancreatitis
  • Severe hyperglycaemia requiring medical intervention
  • Anaphylactic or severe allergic reactions
  • Cardiac arrhythmias
  • Pituitary apoplexy (rare in acromegaly patients)

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Pregnancy: safety not established; use only if benefit outweighs potential risk.
  • Renal impairment: assess renal function and adjust monitoring.
  • Diabetes or impaired glucose tolerance: monitor blood glucose closely.
  • Gallbladder disease: watch for gallstone development during treatment.
  • Concomitant medications: review for possible interactions before prescribing.

Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Co‑administration with other somatostatin analogues: risk of excessive hormonal suppression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase lanreotide exposure.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: possible need for dose adjustment due to altered glucose control.
  • Diuretics: monitor electrolyte balance, especially potassium.
  • Anticoagulants: observe for changes in bleeding tendency.
  • Oral contraceptives: hormonal efficacy may be reduced; consider alternative contraception.

Frequently Asked Questions

Lanreotide Zentiva is prescribed for adult patients with acromegaly to control excess growth hormone production, and for neuroendocrine tumors, including carcinoid syndrome, to manage hormone‑related symptoms and help slow tumor growth.

Lanreotide mimics the natural hormone somatostatin and binds to somatostatin receptors, mainly SSTR2 and SSTR5. This binding blocks intracellular signaling pathways that trigger the release of growth hormone and other peptide hormones, thereby reducing their circulating levels.

The dose of Lanreotide Zentiva is individualized by the prescribing clinician based on the patient’s condition, disease severity, and response to therapy. Healthcare providers determine the appropriate dosing schedule and any necessary adjustments.

Safety data for Lanreotide in pregnancy and lactation are limited. It is classified as having an unknown pregnancy category, and use is generally avoided unless the potential benefit justifies the possible risk to the fetus. Breastfeeding is not recommended without medical advice.

To request Lanreotide Zentiva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Lanreotide and other agents such as octreotide share a similar mechanism of binding somatostatin receptors, but they differ in formulation, dosing frequency, and pharmacokinetic profile. Lanreotide is often administered as a long‑acting injectable, allowing less frequent dosing compared with some short‑acting alternatives.

Lanreotide Zentiva should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

The medication is supplied as a sterile solution for subcutaneous injection. A healthcare professional administers the dose using a pre‑filled syringe or autoinjector, typically into the abdomen or thigh, following aseptic technique.

Serious adverse events, although rare, include acute pancreatitis, severe hyperglycaemia, anaphylactic reactions, cardiac arrhythmias, and, in patients with acromegaly, pituitary apoplexy. Prompt medical attention is required if any of these symptoms arise.

Lanreotide is contraindicated in patients with known hypersensitivity to lanreotide or any of its excipients. Caution is advised for individuals with uncontrolled diabetes, severe gallbladder disease, or those receiving other somatostatin analogues, and it should be avoided in pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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