Product image of Lansoprazol 1 A Pharma (Lansoprazole) supplied by GNH India

Lansoprazol 1 A Pharma

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazol 1 A Pharma (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazol 1 A Pharma, is a proton pump inhibitor presented as an oral formulation for oral use. It reduces gastric acid production and is indicated for conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens, and Zollinger‑Ellison syndrome.

GNH India supplies Lansoprazol 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor used to manage acid‑related gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): lowers esophageal acid exposure and promotes mucosal healing.
  • Peptic ulcer disease: facilitates ulcer healing by suppressing gastric acid secretion.
  • Helicobacter pylori eradication regimens: enhances antibiotic efficacy by creating a less acidic gastric environment.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production associated with gastrin‑secreting tumors.

How It Works

  • Lansoprazole irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces basal and stimulated gastric acid output, leading to an increase in gastric pH and relief of acid‑related symptoms.

Side Effects

Lansoprazole may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: watery stools, usually self‑limiting.
  • Nausea or abdominal discomfort: occasional upset stomach.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis requiring medical attention.
  • Acute interstitial nephritis: kidney inflammation presenting with rash and fever.
  • Hypomagnesemia: low serum magnesium causing muscle cramps or arrhythmias.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.

Precautions & Warnings

Before prescribing Lansoprazole, consider the following precautions.

  • Assess renal function: adjust therapy if severe impairment exists.
  • Evaluate for osteoporosis risk: long‑term use may affect calcium absorption.
  • Monitor for infections: reduced gastric acidity can increase susceptibility to gastrointestinal infections.
  • Review concomitant medications: potential for drug‑drug interactions.
  • Store at ambient temperature: keep below 25°C, protect from moisture and keep in the original packaging.

Avoid Interactions

Lansoprazole can influence the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption; avoid concurrent use.
  • Atazanavir: markedly decreased antiviral levels; contraindicated.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in anticoagulant effect; monitor INR.
  • Digoxin: modest rise in serum concentration; assess for toxicity.
  • Methotrexate (high dose): reduced clearance; monitor renal function and drug levels.

Frequently Asked Questions

Lansoprazol 1 A Pharma contains the proton pump inhibitor lansoprazole and is prescribed to treat acid‑related conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens, and Zollinger‑Ellison syndrome. By lowering gastric acid output, it helps heal mucosal damage and relieves symptoms associated with excess stomach acid.

Lansoprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. This blockade stops the final step of acid secretion, leading to a sustained reduction in gastric acidity and an increase in stomach pH, which promotes healing of acid‑related lesions.

The appropriate dose of lansoprazole is determined by the prescribing clinician based on the specific indication, severity of disease, and patient characteristics. Dosage regimens may vary, and the prescriber will tailor the treatment plan to achieve optimal therapeutic effect while minimizing risk.

Safety data for lansoprazole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should evaluate the individual situation and discuss alternatives before prescribing to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Lansoprazole belongs to the proton pump inhibitor class, offering more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs like omeprazole, it has a similar efficacy profile but may differ in pharmacokinetic properties, such as onset of action and metabolism, which can influence individual patient response.

Store the product at ambient temperature, preferably below 25 °C, in a dry place away from direct sunlight. Keep the tablets in the original container to protect them from moisture and humidity. Do not refrigerate or freeze the product, as temperature extremes may affect its stability.

Lansoprazol 1 A Pharma is taken orally. The tablet should be swallowed whole with a glass of water, preferably before a meal, usually in the morning. It should not be chewed, crushed, or dissolved unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include Clostridioides difficile infection, acute interstitial nephritis, severe hypomagnesemia, and life‑threatening skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience persistent diarrhea, unexplained fever, rash, or muscle cramps while on therapy.

Lansoprazole is contraindicated in individuals with known hypersensitivity to lansoprazole or any other proton pump inhibitor. Caution is advised for patients with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with a history of osteoporosis when used long‑term. A healthcare provider should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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