Product image of Lansoprazol Azevedos (Lansoprazole) supplied by GNH India

Lansoprazol Azevedos

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazol Azevedos (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazol Azevedos, is a proton pump inhibitor presented as an oral tablet for oral administration. It irreversibly blocks the gastric H+/K+ ATPase pump, thereby reducing stomach acid production and providing therapeutic benefit for a range of acid‑related gastrointestinal disorders in adult patients.

GNH India supplies Lansoprazol Azevedos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance for global markets.

Manufacturer / TM Owner

Laboratórios Azevedos - Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Lansoprazole is indicated for several gastrointestinal acid‑related conditions.

  • Gastroesophageal reflux disease (GERD): reduces esophageal acid exposure and alleviates heartburn and regurgitation symptoms.
  • Peptic ulcer disease: promotes ulcer healing by decreasing gastric acidity.
  • Erosive esophagitis: facilitates mucosal repair and symptom control.
  • Helicobacter pylori eradication regimen: used in combination therapy to improve bacterial clearance.

How It Works

  • Lansoprazole irreversibly binds to the sulfhydryl groups of the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly lowers both basal and stimulated gastric acid output, leading to increased gastric pH, ulcer healing and relief of reflux symptoms.

Side Effects

Lansoprazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools often transient.
  • Nausea: occasional feeling of stomach upset.
  • Abdominal pain: cramping or discomfort.
  • Flatulence: increased gas production.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhea.
  • Low magnesium levels: muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Liver enzyme elevation: signs of hepatitis.
  • Acute interstitial nephritis: kidney inflammation.

Precautions & Warnings

When prescribing or dispensing Lansoprazole, consider the following precautions.

  • Assess renal function: dose adjustment may be needed in severe impairment.
  • Evaluate for osteoporosis risk: long‑term use may affect calcium absorption.
  • Review concomitant medications: potential for reduced efficacy of drugs requiring acidic pH.
  • Monitor for infection: prolonged acid suppression can increase risk of gastrointestinal infections.
  • Use cautiously in pregnancy: limited data, weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging and protect from moisture.

Avoid Interactions

Lansoprazole can interact with other medicines, altering their effectiveness or safety.

Major Interactions (Avoid)

  • Antifungal agents (ketoconazole, itraconazole): reduced absorption and efficacy.
  • HIV protease inhibitors (atazanavir, nelfinavir): decreased plasma concentrations.
  • Clopidogrel: diminished antiplatelet activity.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation.
  • Methotrexate: reduced renal clearance, monitor levels.
  • Digoxin: altered absorption, check serum concentrations.
  • Iron supplements: decreased absorption, separate dosing by at least 2 hours.

Frequently Asked Questions

Lansoprazol Azevedos contains the active ingredient lansoprazole, which is prescribed to treat conditions caused by excess stomach acid. These include gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, erosive esophagitis, and it is also used as part of combination therapy for Helicobacter pylori eradication.

Lansoprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This inhibition blocks the final step of acid production, leading to a sustained reduction in gastric acidity and an increase in gastric pH.

The appropriate dose of Lansoprazol Azevedos is determined by the prescribing healthcare professional based on the specific condition being treated, the severity of symptoms, patient age, renal function, and any concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for lansoprazole in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To order Lansoprazol Azevedos, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Lansoprazole belongs to the proton pump inhibitor (PPI) class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs like omeprazole, lansoprazole has a similar efficacy profile but may differ slightly in metabolism and drug‑interaction potential, making individual patient factors important when selecting therapy.

Lansoprazol Azevedos should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Lansoprazol Azevedos is taken orally, usually as a tablet. It is generally recommended to swallow the tablet whole with water, preferably before a meal, unless the prescribing information advises otherwise. The exact timing and frequency should follow the instructions provided by the prescribing clinician.

Serious risks, although uncommon, include severe allergic reactions such as rash, swelling or breathing difficulties, Clostridioides difficile‑associated diarrhea, low magnesium levels that can cause muscle cramps or cardiac arrhythmias, and an increased risk of bone fractures with long‑term use. Patients should seek medical attention if any of these symptoms occur.

Lansoprazol Azevedos should be avoided in individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is also advised for patients with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with a history of osteoporosis when considering long‑term therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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