Product image of Lansoprazol Krka (Lansoprazole) supplied by GNH India

Lansoprazol Krka

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazol Krka (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazol Krka, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid production and is used to treat conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, erosive esophagitis and as part of Helicobacter pylori eradication therapy.

GNH India supplies Lansoprazol Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka Sverige Ab

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Indications & Clinical Uses

Lansoprazol Krka acts on the gastric proton pump to lower acid secretion, benefiting several acid‑related disorders.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and esophageal irritation.
  • Peptic ulcer disease: promotes ulcer healing and prevents recurrence.
  • Erosive esophagitis: reduces mucosal damage and supports recovery.
  • Helicobacter pylori eradication: used in combination therapy to increase eradication rates.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) located on the secretory surface of gastric parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, thereby increasing gastric pH and allowing healing of acid‑related lesions.

Side Effects

Adverse reactions may occur with Lansoprazol Krka use.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools occurring intermittently.
  • Nausea: feeling of stomach upset.
  • Abdominal pain: discomfort in the upper abdomen.
  • Flatulence: increased gas production.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): swelling, difficulty breathing.
  • Clostridium difficile infection: severe colitis with watery diarrhea.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
  • Liver inflammation (hepatitis): jaundice, elevated liver enzymes.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin blistering.
  • Severe skin rash: widespread erythema and itching.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor magnesium levels: long‑term therapy may cause deficiency.
  • Avoid abrupt discontinuation: risk of rebound acid hypersecretion.
  • Use with caution in elderly patients: higher incidence of adverse events.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lansoprazol Krka may interact with several medicines.

Major Interactions (Avoid)

  • Ketoconazole: reduced absorption and efficacy.
  • Atazanavir: decreased antiviral effectiveness.
  • Clopidogrel: reduced activation leading to diminished antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Digoxin: increased serum concentrations.
  • Warfarin: enhanced anticoagulant effect, risk of bleeding.
  • Methotrexate: increased toxicity, especially at high doses.

Frequently Asked Questions

Lansoprazol Krka is a prescription proton pump inhibitor indicated for the treatment of gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, erosive esophagitis, and as part of combination therapy for Helicobacter pylori eradication. By lowering gastric acidity, it relieves symptoms and promotes healing of acid‑related lesions.

Lansoprazole works by irreversibly blocking the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition stops the final step of gastric acid secretion, leading to a sustained increase in gastric pH and reduction of acid‑related damage.

The dosage of Lansoprazol Krka is determined by the prescribing healthcare professional based on the specific indication, patient age, renal function and treatment goals. The prescriber will select the appropriate strength, frequency and duration for each individual case.

Safety data for Lansoprazol Krka in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To order Lansoprazol Krka, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Lansoprazol Krka belongs to the same class as omeprazole, esomeprazole and pantoprazole. All PPIs provide comparable acid suppression, but differences exist in metabolism, drug‑interaction profiles and dosing convenience. Lansoprazole is metabolized primarily by CYP2C19 and CYP3A4, which may affect its interaction potential relative to other PPIs.

Store Lansoprazol Krka at room temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the package is tightly closed to maintain product stability.

Lansoprazol Krka is taken orally. Swallow the tablet whole with a glass of water, preferably before a meal as directed by the prescriber. Do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridium difficile‑associated colitis, low magnesium levels (hypomagnesemia) with prolonged use, liver inflammation, and rare skin disorders like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience symptoms such as rash, persistent diarrhea, muscle cramps, or signs of an allergic reaction.

Lansoprazol Krka should be avoided in individuals with a known hypersensitivity to lansoprazole, other proton pump inhibitors, or any of the tablet’s excipients. Patients with severe liver disease or those taking medications that require an acidic environment for absorption should consult their physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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