Product image of Lansoprazol Krka (Lansoprazole) supplied by GNH India

Lansoprazol Krka

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazol Krka (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazol Krka, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid secretion and is employed in the management of acid‑related gastrointestinal conditions such as reflux disease and ulcers.
GNH India supplies Lansoprazol Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Lansoprazol Krka, a proton pump inhibitor, is used to treat several acid‑related gastrointestinal disorders.

  • Gastroesophageal reflux disease (GERD): reduces acid exposure, relieving heartburn and regurgitation.
  • Peptic ulcer disease: promotes ulcer healing by decreasing gastric acidity.
  • Helicobacter pylori eradication therapy: enhances the effectiveness of antibiotic regimens by suppressing acid production.
  • Erosive esophagitis: facilitates mucosal healing and symptom relief.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) located in the secretory canaliculi of gastric parietal cells. By blocking this final step of acid secretion, it markedly lowers both basal and stimulated gastric acid output, thereby creating a less acidic gastric environment that supports healing of acid‑related lesions.

Side Effects

Adverse reactions may occur with Lansoprazol Krka use.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools, often transient.
  • Nausea: feeling of stomach upset.
  • Abdominal pain: cramping or discomfort.
  • Flatulence: increased gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, difficulty breathing.
  • Clostridioides difficile infection: persistent diarrhea, abdominal pain.
  • Low magnesium levels: muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Liver enzyme elevation: abnormal liver function tests.
  • Acute interstitial nephritis: kidney inflammation presenting with fever and rash.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess renal function: adjust use in severe impairment.
  • Evaluate hepatic status: use with caution in liver disease.
  • Review concomitant medications: potential for altered absorption of drugs requiring acidic pH.
  • Monitor long‑term users: watch for bone density loss and magnesium deficiency.
  • Pregnancy and lactation: discuss risks with a healthcare professional.
  • Store at room temperature: keep below 25°C, in the original packaging, protected from moisture and light.

Avoid Interactions

Lansoprazol Krka may interact with several medicines.

Major Interactions (Avoid)

  • Antifungal agents (e.g., ketoconazole, itraconazole): reduced absorption and efficacy.
  • HIV protease inhibitors (e.g., atazanavir): decreased plasma concentrations.
  • Clopidogrel: diminished antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation.
  • Methotrexate: higher systemic exposure, watch for toxicity.
  • Digoxin: altered absorption, check serum levels.

Frequently Asked Questions

Lansoprazol Krka, containing the active ingredient lansoprazole, is indicated for the management of gastroesophageal reflux disease (GERD), peptic ulcer disease, Helicobacter pylori eradication regimens, and erosive esophagitis. By lowering stomach acid, it helps relieve symptoms, promotes ulcer healing, and supports the effectiveness of antibiotic therapy for H. pylori infection.

Lansoprazole belongs to the proton pump inhibitor class. It binds covalently to the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This irreversible inhibition blocks the final step of acid secretion, leading to a sustained decrease in both basal and stimulated gastric acid output.

The dosage of Lansoprazol Krka is determined by the prescribing healthcare professional based on the specific indication, patient age, renal and hepatic function, and other clinical factors. The prescriber will select the appropriate strength, frequency, and duration of therapy to achieve the desired therapeutic outcome.

Safety of lansoprazole in pregnancy or while nursing has not been definitively established. Healthcare providers should weigh the potential benefits against any possible risks to the fetus or infant. If treatment is considered essential, it should be prescribed after a thorough discussion with the patient and appropriate monitoring.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lansoprazol Krka. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements if applicable), and assists with import documentation.

Lansoprazol Krka is a proton pump inhibitor, offering more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, its efficacy and safety profile are similar, though individual patient response and drug‑interaction potential may vary. Choice of therapy often depends on clinical guidelines, patient tolerance, and drug‑interaction considerations.

Lansoprazol Krka should be stored at room temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture, excessive heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink where humidity levels are high.

Lansoprazol Krka is taken orally, usually as a whole tablet swallowed with water. It is commonly recommended to take the dose before a meal, often in the morning, to maximize acid suppression. Patients should follow the prescriber’s instructions regarding timing, food intake, and whether the tablet may be chewed or crushed.

Serious adverse events, though rare, include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated diarrhea, low magnesium levels leading to muscle cramps or cardiac arrhythmias, and increased risk of bone fractures with long‑term use. Patients should seek immediate medical attention if they experience rash, swelling, persistent diarrhea, or symptoms suggestive of electrolyte imbalance.

Individuals with known hypersensitivity to lansoprazole, other proton pump inhibitors, or any component of the tablet should not use Lansoprazol Krka. Caution is also advised for patients with severe liver disease, those taking clopidogrel, and patients requiring antifungal agents that need an acidic environment for absorption. The prescriber will evaluate suitability on a case‑by‑case basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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