Product image of Lansoprazol Pentafarma Especialidades (Lansoprazole) supplied by GNH India

Lansoprazol Pentafarma Especialidades

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazol Pentafarma Especialidades (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazol Pentafarma Especialidades, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid production and is indicated for the treatment of gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens and Zollinger‑Ellison syndrome in adult patients.

GNH India supplies Lansoprazol Pentafarma Especialidades as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma Especialidades - Sociedade Técnico Medicinal, Lda

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Indications & Clinical Uses

Lansoprazole acts on the gastric proton pump to lower acid secretion, making it useful for several acid‑related conditions.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and esophagitis by reducing gastric acid exposure.
  • Peptic ulcer disease: promotes ulcer healing and prevents recurrence by maintaining a less acidic gastric environment.
  • Helicobacter pylori eradication regimens: used in combination therapy to increase eradication rates.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production associated with gastrin‑secreting tumors.

How It Works

  • Lansoprazole irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, leading to an elevated gastric pH and relief of acid‑related symptoms.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often transient.
  • Diarrhea: loose stools that may resolve with continued therapy.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nausea: feeling of unease or urge to vomit.
  • Flatulence: increased intestinal gas.
  • Constipation: difficulty passing stools.

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome): require immediate medical attention.
  • Clostridioides difficile infection: may cause severe colitis.
  • Elevated liver enzymes: indicate possible hepatic injury.
  • Hypomagnesemia: low magnesium levels with prolonged use.
  • Interstitial nephritis: inflammation of kidney tissue.
  • Acute pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor for infection: prolonged acid suppression can increase risk of C. difficile.
  • Check magnesium levels: long‑term treatment may cause hypomagnesemia.
  • Avoid abrupt discontinuation: may lead to rebound acid hypersecretion.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lansoprazole may interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir: decreased absorption and efficacy.
  • High‑dose methotrexate: increased toxicity.
  • Warfarin: enhanced anticoagulant effect.
  • Digoxin: increased serum concentrations.

Moderate Interactions (Monitor Closely)

  • Cyclosporine: increased blood levels.
  • Phenytoin: reduced anticonvulsant efficacy.
  • Ketoconazole: decreased absorption.
  • Iron supplements: reduced iron absorption.
  • Vitamin B12: possible deficiency with long‑term use.

Frequently Asked Questions

Lansoprazol Pentafarma Especialidades contains lansoprazole, a proton pump inhibitor indicated for gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens and Zollinger‑Ellison syndrome. It works by reducing gastric acid production, helping to heal ulcers and relieve acid‑related symptoms.

Lansoprazole irreversibly inhibits the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. By blocking this final step in acid secretion, it markedly lowers both basal and stimulated gastric acid output, raising the gastric pH and providing symptom relief.

The appropriate dose of Lansoprazol Pentafarma Especialidades is determined by the prescribing healthcare professional based on the specific indication, patient characteristics and clinical guidelines. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Safety in pregnancy and lactation has not been fully established. The drug should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Lansoprazol Pentafarma Especialidades, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lansoprazole belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, its efficacy and safety profile are similar, though individual response and drug‑interaction potential may vary.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

The medication is taken orally, usually as a whole tablet, with water. It can be taken before a meal or as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious risks include severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, Clostridioides difficile infection, low magnesium levels with prolonged use, liver enzyme elevation, interstitial nephritis and, rarely, acute pancreatitis. Patients should seek immediate medical attention if they experience any of these symptoms.

Patients with known hypersensitivity to lansoprazole or any component of the formulation should avoid the product. Caution is also advised for individuals with severe liver disease, those taking interacting medications listed under major interactions, and patients for whom acid suppression is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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