Product image of Lansoprazole Krka (Lansoprazole) supplied by GNH India

Lansoprazole Krka

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazole Krka (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazole Krka, is a proton pump inhibitor presented as an oral dosage form for oral use. It works by inhibiting gastric acid secretion and is indicated for the treatment of gastro‑oesophageal reflux disease, peptic ulcer disease, erosive esophagitis and as part of Helicobacter pylori eradication regimens in adult patients.

GNH India supplies Lansoprazole Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines across multiple markets.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor that reduces gastric acid production, making it useful for several acid‑related gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): relieves heartburn and promotes healing of esophageal erosion.
  • Peptic ulcer disease: accelerates ulcer healing and helps prevent recurrence.
  • Erosive esophagitis: reduces inflammation and facilitates mucosal repair.
  • Helicobacter pylori eradication: used in combination therapy to improve eradication success.

How It Works

  • Lansoprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells in the stomach. By inhibiting this final step of acid secretion, it markedly lowers both basal and stimulated gastric acidity, providing prolonged suppression of gastric acid output.

Side Effects

Lansoprazole may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Constipation

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Clostridioides difficile infection
  • Low magnesium levels (hypomagnesemia)
  • Bone fractures with long‑term use
  • Acute interstitial nephritis
  • Elevated liver enzymes

Precautions & Warnings

When prescribing Lansoprazole, clinicians should consider several safety measures.

  • Assess renal function: dose adjustment may be needed in severe renal impairment.
  • Monitor for infection: prolonged use can increase risk of gastrointestinal infections.
  • Avoid long‑term use without supervision: may be linked to bone fracture risk.
  • Check magnesium levels: prolonged therapy can cause hypomagnesemia.
  • Pregnancy and lactation: use only if benefit outweighs risk (category unknown).
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lansoprazole can affect the pharmacokinetics of several medicines, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir: decreased absorption of atazanavir.
  • Methotrexate: increased toxicity.
  • Warfarin: potential increase in INR.
  • Ketoconazole: reduced antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Diazepam: increased plasma levels.
  • Digoxin: possible increase in serum concentration.
  • Iron supplements: decreased absorption if taken concurrently.
  • Vitamin B12: reduced absorption with long‑term use.
  • HIV protease inhibitors: may require dose adjustment.

Frequently Asked Questions

Lansoprazole Krka is used to lower stomach acid in conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, erosive esophagitis, and as part of combination therapy for Helicobacter pylori eradication. By reducing acid production, it helps relieve symptoms, promotes healing of ulcerated tissue, and prevents recurrence of acid‑related damage.

Lansoprazole works by binding irreversibly to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of stomach parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained decrease in both basal and stimulated gastric acidity.

The appropriate dose of Lansoprazole Krka is determined by the prescribing clinician based on the specific indication, patient age, renal function and other clinical factors. Typical adult regimens range from once‑daily to twice‑daily dosing, but the exact strength and schedule should follow the prescriber’s order.

The safety of Lansoprazole Krka during pregnancy or lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Lansoprazole Krka, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lansoprazole belongs to the proton pump inhibitor (PPI) class, which generally provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs like omeprazole, lansoprazole has a similar efficacy profile but may differ slightly in metabolism and drug‑interaction potential, making individual patient factors important in selection.

Lansoprazole Krka should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.

Lansoprazole Krka is taken orally, usually as a tablet or capsule. It should be swallowed whole with a glass of water, preferably before a meal, unless the prescribing information advises otherwise. Do not crush, chew, or split the dosage form unless instructed by a healthcare professional.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, Clostridioides difficile‑associated diarrhea, low magnesium (hypomagnesemia) with prolonged use, increased risk of bone fractures, and acute interstitial nephritis. Patients should be monitored for these events, especially during long‑term therapy.

Lansoprazole Krka should not be used by individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is also advised in patients with severe liver disease, those taking certain interacting medications (e.g., clopidogrel), and in cases where the benefit does not outweigh potential risks, such as during pregnancy without medical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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