Product image of Lansoprazole Pliva Pharma (Lansoprazole) supplied by GNH India

Lansoprazole Pliva Pharma

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazole Pliva Pharma (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazole Pliva Pharma, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid production and is used to treat conditions such as gastro‑esophageal reflux disease, peptic ulcer disease, and Zollinger‑Ellison syndrome in adult patients.

GNH India supplies Lansoprazole Pliva Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, with a focus on reliable quality, regulatory compliance, and timely delivery across multiple global and regional markets.

Manufacturer / TM Owner

Pliva Pharma Limited

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor used to manage acid‑related gastrointestinal disorders.

  • Gastro‑esophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal erosion.
  • Peptic ulcer disease: promotes ulcer healing and reduces recurrence.
  • Helicobacter pylori eradication (as part of combination therapy): enhances eradication rates by suppressing gastric acid.
  • Zollinger‑Ellison syndrome: controls hypersecretion of gastric acid.

How It Works

  • Lansoprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells in the stomach. By inhibiting this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, leading to increased gastric pH. The inhibition persists for up to 72 hours because new enzyme synthesis is required for acid production to resume.

Side Effects

Lansoprazole may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Diarrhea: loose stools that may resolve with continued therapy.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nausea: feeling of queasiness, usually mild.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis): swelling, rash, difficulty breathing.
  • Clostridioides difficile infection: severe diarrhea and colitis.
  • Stevens‑Johnson syndrome: skin blistering and mucosal involvement.
  • Liver enzyme elevation: signs of hepatic dysfunction.
  • Hypomagnesemia: low magnesium levels with prolonged use.

Precautions & Warnings

When prescribing Lansoprazole, consider the following precautions.

  • Assess renal function: dose adjustment may be needed in severe renal impairment.
  • Monitor for drug interactions: avoid concomitant use with drugs that require gastric acidity for absorption.
  • Use with caution in patients with hepatic impairment: consider dose reduction.
  • Avoid prolonged use without medical supervision: risk of nutrient malabsorption.
  • Pregnancy and lactation: consult healthcare provider before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can interact with several medications.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir: decreased absorption of atazanavir.
  • Methotrexate: increased toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increased INR.
  • Diazepam: increased plasma levels.
  • Digoxin: may increase serum concentration.

Frequently Asked Questions

Lansoprazole Pliva Pharma is used to treat acid‑related gastrointestinal conditions such as gastro‑esophageal reflux disease, peptic ulcer disease, Helicobacter pylori infection (as part of combination therapy), and Zollinger‑Ellison syndrome. It works by reducing the amount of acid produced in the stomach, which helps heal and prevent damage.

Lansoprazole works by binding irreversibly to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of stomach parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained increase in gastric pH and reduced acidity.

The appropriate dose of Lansoprazole Pliva Pharma is determined by a qualified prescriber based on the specific condition being treated, patient age, renal and hepatic function, and other clinical factors. Patients should follow the prescribing information provided by their healthcare professional.

Safety of Lansoprazole during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy.

To order Lansoprazole Pliva Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Lansoprazole belongs to the same class as omeprazole, esomeprazole, pantoprazole, and rabeprazole. All inhibit the gastric proton pump, but they differ in pharmacokinetic profiles, potency, and drug‑interaction potential. Clinicians may choose based on patient response, drug‑interaction considerations, and formulary preferences.

Lansoprazole Pliva Pharma should be stored at room temperature, typically below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain stability and potency throughout the shelf life.

Lansoprazole Pliva Pharma is taken orally, usually as a tablet swallowed whole with water. It is generally recommended to take the dose before a meal, often in the morning, unless otherwise directed by a healthcare professional.

Serious risks, though uncommon, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, Stevens‑Johnson syndrome, liver enzyme abnormalities, and low magnesium levels with long‑term use. Patients should seek immediate medical attention if they experience symptoms like rash, persistent diarrhea, or muscle weakness.

Individuals with known hypersensitivity to lansoprazole or any component of the formulation should avoid its use. Patients with severe liver disease, those taking interacting medications such as clopidogrel without medical guidance, and patients for whom acid suppression is contraindicated should also refrain from using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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