Product image of Lansoprazole Ranbaxy (Uk) (Lansoprazole) supplied by GNH India

Lansoprazole Ranbaxy (Uk)

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazole Ranbaxy (Uk) (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazole Ranbaxy, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid production and is used to treat acid‑related disorders such as gastro‑oesophageal reflux disease and peptic ulcer disease.
GNH India supplies Lansoprazole Ranbaxy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun Pharma Uk Limited

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor that addresses conditions caused by excess gastric acid.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of the oesophageal lining.
  • Peptic ulcer disease: supports ulcer healing and reduces recurrence.
  • Erosive esophagitis: aids mucosal repair and reduces inflammation.
  • Helicobacter pylori eradication (in combination therapy): enhances eradication rates when used with antibiotics.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid secretion, it markedly lowers both basal and stimulated gastric acid output, creating a less acidic gastric environment that facilitates healing of acid‑related mucosal damage.

Side Effects

Lansoprazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: occasional loose stools.
  • Nausea: transient feeling of queasiness.
  • Abdominal pain: mild discomfort in the stomach area.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reactions.
  • Clostridioides difficile infection: severe colitis.
  • Severe liver injury: jaundice or hepatic dysfunction.
  • Anaphylaxis: life‑threatening allergic response.
  • Interstitial nephritis: kidney inflammation.
  • Bone fractures: increased risk with long‑term use.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Renal function assessment: adjust use in severe renal impairment.
  • Hepatic monitoring: evaluate liver function for prolonged treatment.
  • Long‑term use caution: monitor for increased risk of bone fractures.
  • Elderly patients: use the lowest effective dose and monitor for adverse effects.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can affect the pharmacokinetics of several medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir: decreased antiviral efficacy.
  • HIV protease inhibitors (e.g., ritonavir): lowered plasma concentrations.
  • Methotrexate: increased toxicity risk.
  • Voriconazole: reduced antifungal activity.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of INR.
  • Digoxin: increased serum levels.
  • Phenytoin: reduced anticonvulsant effect.
  • Rifampin: decreased lansoprazole exposure.
  • Theophylline: possible increased plasma concentration.

Frequently Asked Questions

Lansoprazole Ranbaxy is indicated for the management of acid‑related disorders such as gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, erosive oesophagitis, and as part of combination therapy for Helicobacter pylori eradication. It works by reducing gastric acid secretion, which helps heal and prevent damage to the gastrointestinal lining.

Lansoprazole belongs to the proton pump inhibitor class. It binds irreversibly to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. By inhibiting this enzyme, it blocks the final step of acid production, leading to a significant reduction in both basal and stimulated gastric acid output.

The appropriate dose of Lansoprazole Ranbaxy is determined by a qualified prescriber based on the specific indication, patient characteristics, and clinical response. Healthcare professionals consider factors such as disease severity, renal and hepatic function, and concomitant medications when selecting the dosage regimen.

Safety data for Lansoprazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in breast milk and could affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lansoprazole, as a proton pump inhibitor, provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, its efficacy is comparable, though individual response and drug‑interaction profiles may differ. Choice of therapy often depends on patient tolerance, drug‑interaction potential, and clinical guidelines.

Lansoprazole Ranbxy should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Lansoprazole is taken orally, usually as a tablet, with a glass of water. It is generally recommended to swallow the tablet whole, preferably before a meal, to ensure optimal absorption and acid‑suppression effect. Patients should follow the prescriber’s instructions regarding timing and frequency.

Serious but rare risks include severe skin reactions such as Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, liver injury, anaphylaxis, interstitial nephritis, and increased risk of bone fractures with long‑term therapy. Patients should seek immediate medical attention if they experience symptoms like rash, severe abdominal pain, jaundice, or unexplained swelling.

Lansoprazole is contraindicated in individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is advised for patients with severe hepatic impairment, those on medications with major interactions (e.g., clopidogrel), and patients with a history of certain rare adverse reactions. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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