Product image of Lansoprazole Teva (Lansoprazole) supplied by GNH India

Lansoprazole Teva

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazole Teva (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazole Teva, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid production and is indicated for the treatment of gastro‑oesophageal reflux disease, peptic ulcer disease, and as part of Helicobacter pylori eradication regimens in adult patients.

GNH India supplies Lansoprazole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, with established distribution networks and regulatory expertise across EU and global markets for a broad range of therapeutic needs.

Manufacturer / TM Owner

Teva Pharma Belgium N.V./S.A

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor used to manage conditions associated with excess gastric acid secretion.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and esophageal irritation by reducing acid exposure.
  • Peptic ulcer disease: promotes healing of gastric and duodenal ulcers through sustained acid suppression.
  • Helicobacter pylori eradication: used in combination therapy to increase eradication rates by creating a less acidic gastric environment.

How It Works

  • Lansoprazole irreversibly binds to the H⁺/K⁺‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly decreases basal and stimulated gastric acid secretion, leading to an elevated gastric pH that facilitates ulcer healing and symptom relief. The inhibition is sustained for up to 72 hours because the pump must synthesize new enzyme molecules to restore function.

Side Effects

Lansoprazole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild, transient headache reported by some patients.
  • Diarrhea: loose stools occurring during early treatment.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild discomfort in the stomach region.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis associated with altered gut flora.
  • Acute interstitial nephritis: inflammation of kidney interstitium requiring medical attention.
  • Hypomagnesemia: low serum magnesium levels that may cause muscle cramps or arrhythmias.
  • Stevens‑Johnson syndrome: rare severe skin reaction with blistering and mucosal involvement.

Precautions & Warnings

Before prescribing Lansoprazole, clinicians should consider several precautionary measures to ensure safe use.

  • Assess renal function: dose adjustment may be required in severe renal impairment.
  • Evaluate for CYP2C19 polymorphisms: altered metabolism can affect drug exposure.
  • Monitor long‑term use: prolonged therapy has been linked to increased risk of fractures and vitamin B12 deficiency.
  • Use with caution in patients with liver disease: hepatic impairment may increase systemic exposure.
  • Discontinue before surgery: consider stopping the drug prior to procedures requiring gastric acidity.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can affect the pharmacokinetics of several concomitant medicines, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect due to impaired activation.
  • Atazanavir: decreased absorption leading to loss of antiviral efficacy.
  • Dasatinib: lowered plasma concentrations compromising cancer therapy.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, requiring more frequent monitoring.
  • Methotrexate: reduced renal clearance may raise toxicity risk.
  • Digoxin: modest increase in serum levels, monitor for signs of toxicity.

Frequently Asked Questions

Lansoprazole Teva is indicated for the treatment of gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, and as part of combination regimens to eradicate Helicobacter pylori infection. By lowering gastric acidity, it helps relieve symptoms, promotes ulcer healing, and improves the effectiveness of antibiotic therapy against H. pylori.

Lansoprazole works by irreversibly inhibiting the H⁺/K⁺‑ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This blockade prevents the final step of acid secretion, leading to a sustained increase in gastric pH and reduced acidity, which underlies its therapeutic effects.

The appropriate dose of Lansoprazole Teva is determined by the prescribing healthcare professional based on the specific indication, severity of disease, patient age, renal and hepatic function, and any concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions and local labeling.

Safety data for lansoprazole in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding mothers should consult their physician, as the drug is excreted in small amounts in breast milk and the decision should be individualized.

To order Lansoprazole Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, and will request verification of trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details and any necessary import documentation.

Lansoprazole belongs to the same class as omeprazole, esomeprazole, pantoprazole and rabeprazole. All share the same mechanism of irreversible proton‑pump inhibition, but they differ slightly in pharmacokinetic profiles, potency, and drug‑interaction potential. Clinical efficacy is generally comparable, while individual patient response and tolerance may guide the choice of one PPI over another.

Lansoprazole Teva should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms. No refrigeration is required for this oral tablet formulation.

Lansoprazole Teva is taken orally, usually as a whole tablet swallowed with water. It is commonly administered before a meal, often in the morning, but the exact timing should follow the prescriber’s instructions. The tablet should not be crushed, chewed, or split unless specifically advised by a healthcare professional.

Serious but rare risks include Clostridioides difficile‑associated diarrhea, acute interstitial nephritis, hypomagnesemia, and severe cutaneous reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should be advised to seek immediate medical attention if they experience persistent diarrhea, unexplained muscle cramps, rash, or blistering skin lesions.

Lansoprazole is contraindicated in individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is advised for patients with severe liver disease, those taking medications that require an acidic gastric environment for absorption, and patients with a history of allergic reactions to other proton pump inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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