Lansoprazole Teva Sante (Lansoprazole)

Lansoprazole is a proton pump inhibitor used to treat disorders related to excess gastric acid production.

• Gastro‑oesophageal reflux disease (GERD): reduces acid reflux symptoms and promotes healing of esophageal irritation.
• Peptic ulcer disease: facilitates ulcer healing by decreasing gastric acidity.
• Helicobacter pylori eradication (in combination therapy): enhances the effectiveness of antibiotic regimens by creating a less acidic environment.
• Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid associated with gastrin‑producing tumors.

• Lansoprazole selectively and irreversibly inhibits the H⁺/K⁺‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, leading to an increase in gastric pH. The inhibition persists for up to 72 hours, allowing once‑daily dosing in most treatment regimens and contributes to sustained symptom relief.

Lansoprazole may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Headache: mild to moderate intensity, often transient.
• Diarrhea: loose stools, usually short‑term.
• Nausea: feeling of stomach upset, may improve with food.
• Abdominal pain: discomfort in the stomach area, intermittent.
• Flatulence: increased intestinal gas, can cause bloating.
• Constipation: reduced bowel movements, may be relieved with fiber.

Serious or Rare Side Effects

• Severe allergic reaction: rash, itching, swelling, or difficulty breathing, requiring immediate medical attention.
• Clostridioides difficile infection: persistent diarrhea with abdominal pain, may occur after prolonged therapy.
• Low magnesium levels: muscle cramps, irregular heartbeat, or seizures, especially with long‑term use.
• Bone fractures: increased risk with long‑term use, particularly in elderly patients.
• Liver enzyme elevation: signs of hepatic dysfunction, such as jaundice or fatigue.

Before prescribing Lansoprazole, consider the following precautions to ensure safe use.

• Assess renal function: dose adjustment may be needed in severe impairment.
• Evaluate for H. pylori infection: confirm eradication after therapy completion.
• Monitor long‑term use: prolonged therapy may increase risk of fractures and vitamin B12 deficiency.
• Review concomitant medications: potential interactions with drugs requiring acidic environment.
• Use in pregnancy and lactation: only if clearly needed, as safety data are limited.
• Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Lansoprazole can affect the plasma concentrations of several co‑administered medicines.

Major Interactions (Avoid)

• Ketoconazole: reduced absorption leading to therapeutic failure.
• Atazanavir: decreased plasma levels, compromising antiviral efficacy.
• Clopidogrel: diminished activation, reducing antiplatelet effect.

Moderate Interactions (Monitor Closely)

• Warfarin: possible increase in INR, requiring closer monitoring.
• Digoxin: higher serum concentrations may occur.
• Methotrexate (high dose): increased toxicity risk.
• Iron supplements: decreased absorption, consider separate dosing times.