Product image of Lansoprazole Zydus (Lansoprazole) supplied by GNH India

Lansoprazole Zydus

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazole Zydus (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazole Zydus, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease and erosive oesophagitis.

GNH India supplies Lansoprazole Zydus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zydus France

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor used to manage acid‑related gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief by reducing gastric acid exposure to the esophagus.
  • Peptic ulcer disease: promotes ulcer healing by maintaining a higher gastric pH.
  • Erosive oesophagitis: facilitates mucosal recovery through sustained acid suppression.
  • Helicobacter pylori eradication (in combination therapy): enhances eradication rates when used with antibiotics.

How It Works

  • Lansoprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the proton pump) located on the secretory surface of gastric parietal cells. By inhibiting this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, leading to an elevated gastric pH that persists for up to 24 hours after a single dose.

Side Effects

Lansoprazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: watery stools.
  • Nausea: feeling of queasiness.
  • Abdominal pain: discomfort in the stomach area.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis.
  • Acute interstitial nephritis: kidney inflammation.
  • Severe allergic reaction: rash, swelling, difficulty breathing.

Precautions & Warnings

Before prescribing Lansoprazole, consider the following precautions.

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Evaluate hepatic status: use with caution in moderate to severe liver disease.
  • Monitor long‑term therapy: prolonged use may increase risk of bone fractures.
  • Review concomitant medications: potential for reduced efficacy of drugs requiring acidic pH.
  • Pregnancy and lactation: safety not established; prescribe only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture.

Avoid Interactions

Lansoprazole can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Antifungal agents (ketoconazole, itraconazole): reduced absorption due to increased gastric pH.
  • HIV protease inhibitors (atazanavir, nelfinavir): decreased plasma concentrations.
  • Warfarin: potential increase in INR, monitor coagulation.

Moderate Interactions (Monitor Closely)

  • Clopidogrel: reduced antiplatelet effect.
  • Digoxin: increased serum levels.
  • Methotrexate: higher exposure, especially at high doses.
  • Oral contraceptives: possible decreased efficacy.

Frequently Asked Questions

Lansoprazole Zydus is indicated for the treatment of gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, erosive oesophagitis, and it is also used as part of combination therapy for Helicobacter pylori eradication.

Lansoprazole inhibits the H+/K+ ATPase enzyme, also known as the proton pump, on gastric parietal cells. This blocks the final step of acid secretion, leading to a sustained increase in gastric pH and reduced acidity.

The appropriate dose and duration of Lansoprazole Zydus are determined by the prescribing healthcare professional based on the specific condition, severity, and patient factors. Patients should follow the prescriber’s instructions.

Safety data for Lansoprazole Zydus in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lansoprazole and omeprazole belong to the same class of proton pump inhibitors and share a similar mechanism of action. Differences may exist in pharmacokinetic profiles, dosing frequency, and individual patient response, which are evaluated by the prescriber.

Lansoprazole Zydus tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep out of reach of children.

The medication is taken orally as a tablet. It should be swallowed whole with a glass of water, and can be taken with or without food, unless the prescriber provides specific instructions.

Serious but rare adverse effects include Clostridioides difficile‑associated colitis, acute interstitial nephritis, and severe allergic reactions such as rash, swelling or breathing difficulty. Patients should seek immediate medical attention if these occur.

Patients with known hypersensitivity to lansoprazole or any component of the formulation should avoid the drug. Caution is also advised for individuals with severe liver disease, certain renal impairments, and those taking medications that may have major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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