Lansoprazolo Aurobindo (Lansoprazole)

Lansoprazolo Aurobindo is a proton pump inhibitor used to manage acid‑related disorders of the gastrointestinal tract.

• Gastro‑esophageal reflux disease (GERD): provides symptomatic relief by decreasing reflux of acidic gastric contents.
• Peptic ulcer disease: promotes ulcer healing by maintaining a low‑acid environment.
• Helicobacter pylori eradication (in combination therapy): enhances the effectiveness of antibiotic regimens.
• Prevention of NSAID‑induced gastric ulcers: reduces the risk of ulcer formation in patients requiring non‑steroidal anti‑inflammatory drugs.

• Lansoprazole irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly suppresses gastric acid secretion, leading to increased gastric pH and allowing healing of acid‑related mucosal lesions.

Lansoprazolo Aurobindo may be associated with a range of adverse reactions.

Common Side Effects

• Headache: mild to moderate pain often transient.
• Diarrhea: loose stools that may resolve with continued therapy.
• Nausea: feeling of unease or upset stomach.
• Abdominal pain: discomfort in the upper abdomen.
• Flatulence: increased gas production.
• Constipation: reduced bowel movements.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis): swelling, difficulty breathing, rash.
• Clostridioides difficile infection: persistent watery diarrhea, abdominal cramping.
• Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
• Bone fractures (with long‑term use): increased risk of hip, wrist, or spine fractures.
• Liver enzyme elevation: signs of hepatitis such as jaundice.
• Acute interstitial nephritis: kidney inflammation presenting with fever and rash.

Before initiating therapy, consider the following precautions.

• Assess renal function: dose adjustment may be needed in severe impairment.
• Evaluate hepatic status: monitor for liver enzyme changes.
• Review concomitant medications: potential for drug‑drug interactions.
• Use with caution in the elderly: higher risk of fractures and infections.
• Avoid prolonged use without medical supervision: risk of nutrient deficiencies.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Lansoprazolo Aurobindo can affect the pharmacokinetics of several drugs.

Major Interactions (Avoid)

• Ketoconazole and itraconazole: reduced antifungal absorption.
• Atazanavir and nelfinavir: decreased antiviral efficacy.
• Warfarin: potential increase in anticoagulant effect.

Moderate Interactions (Monitor Closely)

• Digoxin: possible increase in serum levels.
• Methotrexate (high dose): enhanced toxicity risk.
• Clopidogrel: reduced antiplatelet activity.
• Iron supplements: decreased iron absorption.
• Vitamin B12: long‑term therapy may impair absorption.