Product image of Lansoprazolo Hexal (Lansoprazole) supplied by GNH India

Lansoprazolo Hexal

Active Ingredient:
Lansoprazole
Origin:
EU

Lansoprazolo Hexal (Lansoprazole)

Lansoprazole, the active ingredient in Lansoprazolo Hexal, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease and related disorders in adult patients.

GNH India supplies Lansoprazolo Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz S.P.A.

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Indications & Clinical Uses

Lansoprazole acts on the gastric acid‑secretion pathway and is indicated for several acid‑related disorders.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and regurgitation by reducing stomach acidity.
  • Peptic ulcer disease: promotes ulcer healing and prevents recurrence through acid suppression.
  • Helicobacter pylori eradication regimens: enhances antibiotic effectiveness when combined with clarithromycin and amoxicillin.
  • Erosive esophagitis: heals inflamed esophageal tissue by maintaining a higher gastric pH.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (the proton pump) located on the secretory surface of gastric parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, leading to an increased gastric pH and facilitating mucosal healing in acid‑related diseases.

Side Effects

Lansoprazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate pain in the head region.
  • Diarrhea: loose, frequent stools.
  • Nausea: sensation of unease and urge to vomit.
  • Abdominal pain: discomfort or cramps in the stomach area.
  • Flatulence: excess gas causing bloating.
  • Constipation: difficulty passing stools.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Clostridium difficile infection: severe colitis presenting with watery diarrhea.
  • Liver enzyme elevation: increased ALT or AST indicating hepatic stress.
  • Stevens‑Johnson syndrome: painful skin blistering and mucosal involvement.
  • Acute interstitial nephritis: kidney inflammation causing reduced urine output.
  • Pancreatitis: inflammation of the pancreas with abdominal pain and vomiting.

Precautions & Warnings

Before prescribing Lansoprazole, clinicians should consider several safety aspects.

  • Renal function assessment: adjust use in patients with severe kidney impairment.
  • Hepatic impairment: monitor liver function tests during therapy.
  • Known hypersensitivity: avoid in individuals with documented allergy to lansoprazole or other PPIs.
  • Long‑term use monitoring: be aware of potential increased risk of bone fractures and vitamin B12 deficiency.
  • Drug interaction vigilance: review concomitant medications that may affect metabolism.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can affect the plasma concentrations of several co‑administered drugs.

Major Interactions (Avoid)

  • Clarithromycin: may increase lansoprazole levels, raising risk of toxicity.
  • Ketoconazole: reduced absorption of ketoconazole leading to therapeutic failure.
  • Atazanavir: decreased atazanavir exposure, compromising antiviral efficacy.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may lower lansoprazole concentrations, requiring efficacy monitoring.
  • Carbamazepine: can reduce lansoprazole exposure, potentially diminishing acid suppression.

Frequently Asked Questions

Lansoprazolo Hexal contains lansoprazole, a proton pump inhibitor that is used to treat acid‑related conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens and erosive esophagitis. By lowering stomach acidity, it helps relieve symptoms and promotes healing of the gastrointestinal lining.

Lansoprazole works by irreversibly binding to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition blocks the final step of gastric acid production, leading to a sustained reduction in stomach acidity and allowing damaged mucosal tissue to heal.

The appropriate dose of Lansoprazolo Hexal is determined by the prescribing healthcare professional based on the specific indication, patient age, renal and hepatic function, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety data for lansoprazole in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case individually and advise accordingly.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details and any required import documentation.

Lansoprazolo Hexal, like other PPIs, provides potent acid suppression. Compared with some alternatives, lansoprazole has a rapid onset of action and a favorable pharmacokinetic profile, but individual response and drug‑interaction potential may differ. Choice of PPI often depends on physician preference, patient tolerance and specific drug‑interaction considerations.

Lansoprazolo Hexal should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency throughout its shelf life.

Lansoprazolo Hexal is taken orally, usually as a tablet. It is generally recommended to swallow the tablet whole with a glass of water, preferably before a meal, unless the prescribing clinician advises otherwise.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Clostridium difficile‑associated diarrhea, liver enzyme elevations, Stevens‑Johnson syndrome, acute interstitial nephritis and pancreatitis. Patients should seek immediate medical attention if they experience symptoms like rash, persistent diarrhea, jaundice, or unexplained abdominal pain.

Individuals with a known hypersensitivity to lansoprazole, other proton pump inhibitors, or any of the tablet’s excipients should avoid using Lansoprazolo Hexal. Additionally, patients with severe liver disease, certain metabolic disorders, or those taking medications that have major interactions with lansoprazole should consult their healthcare provider before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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