Product image of Lantarel Fs (Methotrexate Disodium) supplied by GNH India

Lantarel Fs

Active Ingredient:
Methotrexate Disodium
Origin:
EU

Lantarel Fs (Methotrexate Disodium)

Methotrexate, the active ingredient in Lantarel Fs, is an antimetabolite (folate antagonist) presented as an injectable formulation for intramuscular, intravenous, and subcutaneous administration. It is used to manage rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and ectopic pregnancy in suitable patients.

GNH India supplies Lantarel Fs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Pfizer Pharma Gmbh

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Indications & Clinical Uses

  • Methotrexate is employed in several disease categories where inhibition of folate metabolism is therapeutic.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin cell proliferation and improves lesions.
  • Acute lymphoblastic leukemia: induces remission by halting malignant cell proliferation.
  • Non‑Hodgkin lymphoma: contributes to tumor control through cytotoxic effects.
  • Ectopic pregnancy: terminates trophoblastic tissue to avoid surgical intervention.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate. This limits the cellular pool of tetrahydrofolate required for synthesis of purine nucleotides and thymidylate, thereby impairing DNA, RNA and protein synthesis. The resulting antiproliferative effect is most pronounced in rapidly dividing cells, including immune cells and malignant lymphoid or myeloid cells.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Fatigue: general tiredness.
  • Elevated liver enzymes: mild hepatic enzyme increase.

Serious or Rare Side Effects

  • Severe liver toxicity: hepatitis or fibrosis.
  • Pulmonary fibrosis: interstitial lung disease.
  • Bone marrow suppression: pancytopenia or severe leukopenia.

Precautions & Warnings

When using methotrexate, several precautions should be observed to minimize risks.

  • Pregnancy: contraindicated; teratogenic (Category X).
  • Renal function: assess before and during therapy; dose adjust if impairment.
  • Hepatic monitoring: regular liver function tests required.
  • Hematologic monitoring: periodic complete blood counts to detect suppression.
  • Concomitant drugs: avoid NSAIDs and other folate antagonists without supervision.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or toxicity.

Major Interactions (Avoid)

  • NSAIDs: increase methotrexate toxicity by reducing renal clearance.
  • Proton pump inhibitors: may raise methotrexate levels.
  • Trimethoprim‑sulfamethoxazole: additive bone marrow suppression.

Moderate Interactions (Monitor Closely)

  • Azathioprine: combined immunosuppression risk.
  • Live vaccines: risk of infection due to immunosuppression.
  • Vitamin B12 or folic acid supplements: may reduce efficacy, require dose adjustment.

Frequently Asked Questions

Lantarel Fs contains methotrexate, which is indicated for the treatment of rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and ectopic pregnancy. It works by modulating immune activity and inhibiting rapid cell proliferation in these conditions.

Methotrexate blocks the enzyme dihydrofolate reductase, preventing the formation of tetrahydrofolate needed for DNA, RNA and protein synthesis. This inhibition reduces the growth of rapidly dividing cells, including immune cells involved in inflammation and malignant cells in certain cancers.

The dose of Lantarel Fs is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and response to therapy. No fixed dosing regimen is provided here; the prescriber sets the appropriate amount.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal malformations or death. It is also not recommended while breastfeeding, as it may be excreted in milk and affect the infant.

To order Lantarel Fs, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with other disease‑modifying agents, methotrexate offers a well‑established efficacy profile for autoimmune diseases and certain cancers at a relatively low cost. Biologic agents may provide targeted action but are generally more expensive and require subcutaneous or intravenous infusion, whereas methotrexate can be given by multiple injection routes.

Lantarel Fs should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product to maintain stability.

Lantarel Fs is supplied as an injectable solution and may be given intramuscularly, intravenously, or subcutaneously according to the prescriber’s instructions. Administration technique follows standard aseptic injection practices.

Serious risks include severe liver toxicity (hepatitis or fibrosis), pulmonary fibrosis, profound bone‑marrow suppression leading to pancytopenia, and teratogenic effects that can cause fetal malformations. Patients should be monitored regularly for liver function, blood counts and respiratory symptoms.

Lantarel Fs should not be used by pregnant women, individuals with known hypersensitivity to methotrexate, patients with severe renal or hepatic impairment, and those receiving live vaccines without medical supervision. Contraindications are determined by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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