Product image of Lanthanum Orifarm (Lanthanum) supplied by GNH India

Lanthanum Orifarm

Active Ingredient:
Lanthanum
Origin:
EU

Lanthanum Orifarm (Lanthanum)

Lanthanum carbonate, the active ingredient in Lanthanum Orifarm, is a phosphate binder presented as an oral tablet for gastrointestinal administration. It reduces dietary phosphate absorption and is indicated for the management of hyperphosphatemia in chronic kidney disease patients, particularly those receiving dialysis.

The product is manufactured in the European Union and meets EU quality standards, ensuring consistent potency and safety for patients. GNH India supplies Lanthanum Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Lanthanum Orifarm is a phosphate binder used to control elevated serum phosphate in renal‑related conditions.

  • Chronic kidney disease with hyperphosphatemia: helps lower serum phosphate levels.
  • End‑stage renal disease (ESRD) requiring phosphate control: reduces dietary phosphate absorption.
  • Dialysis patients with hyperphosphatemia: assists in maintaining target phosphate concentrations.

How It Works

  • Lanthanum carbonate acts locally in the gastrointestinal tract. The lanthanum ions bind dietary phosphate to form insoluble lanthanum phosphate complexes that are not absorbed. By reducing the amount of absorbable phosphate, serum phosphate concentrations decrease, helping to control hyperphosphatemia in patients with impaired renal excretion. The binding process is pH‑dependent and occurs throughout the stomach and intestines, providing a sustained reduction in phosphate uptake with each dose.

Side Effects

Lanthanum Orifarm may cause adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Nausea: occasional upset stomach.
  • Constipation: reduced bowel movements.
  • Abdominal pain: mild discomfort.
  • Diarrhea: loose stools.
  • Flatulence: increased gas.
  • Dyspepsia: indigestion.

Serious or Rare Side Effects

  • Severe constipation or bowel obstruction: requires medical attention.
  • Allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Severe abdominal pain: persistent or worsening pain.
  • Hypophosphatemia: excessively low phosphate levels.
  • Hypercalcemia: elevated calcium levels, especially when combined with calcium supplements.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor serum phosphate: adjust dose based on laboratory results.
  • Assess calcium balance: avoid concurrent high calcium intake.
  • Gastrointestinal disorders: use cautiously in patients with bowel obstruction or severe constipation.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Renal function: dose may need adjustment in severe renal impairment.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Lanthanum carbonate can affect the absorption of several co‑administered drugs.

Major Interactions (Avoid)

  • Tetracycline antibiotics: binding reduces antibiotic efficacy.
  • Fluoroquinolone antibiotics: decreased absorption when taken together.
  • Levothyroxine: may lower thyroid hormone levels.
  • Iron supplements: significant reduction in iron absorption.
  • Vitamin B12: decreased uptake with concurrent use.

Moderate Interactions (Monitor Closely)

  • Calcium carbonate: may diminish phosphate‑binding capacity.
  • Vitamin D analogues: monitor calcium‑phosphate product.
  • Magnesium‑containing antacids: possible reduced effectiveness of lanthanum.
  • Sevelamer: assess combined phosphate‑binding effect.
  • Proton pump inhibitors: may alter gastric pH and affect binding efficiency.

Frequently Asked Questions

Lanthanum Orifarm contains lanthanum carbonate, a phosphate binder that is prescribed to lower elevated serum phosphate levels in patients with chronic kidney disease or those undergoing dialysis. By binding dietary phosphate in the gut, it helps manage hyperphosphatemia, a common complication of reduced kidney function.

Lanthanum carbonate works locally in the gastrointestinal tract. The lanthanum ions bind to dietary phosphate, forming insoluble lanthanum phosphate complexes that are not absorbed. This reduces the amount of phosphate entering the bloodstream, thereby lowering serum phosphate concentrations in patients with impaired renal excretion.

The appropriate dose of Lanthanum Orifarm is determined by the prescribing clinician based on the patient’s serum phosphate levels, dietary phosphate intake, and overall renal function. The prescriber will adjust the tablet strength and frequency to achieve target phosphate control.

The safety of lanthanum carbonate in pregnancy and lactation has not been fully established, and the product’s pregnancy category is listed as unknown. Healthcare providers should weigh the potential benefits against any possible risks before prescribing it to pregnant or nursing women.

To place an order, submit an enquiry on the Lanthanum Orifarm product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lanthanum Orifarm is a non‑calcium phosphate binder, which can be advantageous for patients who need to limit calcium intake. Compared with calcium‑based binders, it may result in lower calcium load and reduced risk of vascular calcification, while offering similar efficacy in lowering serum phosphate.

Lanthanum Orifarm tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect the product from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

The tablets are taken orally, usually with meals or as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed, as this could affect the binding capacity.

Serious risks include severe constipation that may lead to bowel obstruction, allergic reactions such as rash or anaphylaxis, and rare cases of hepatic dysfunction. Patients should report any persistent abdominal pain, swelling, or signs of an allergic response to their healthcare provider promptly.

Lanthanum Orifarm should be avoided in individuals with known hypersensitivity to lanthanum carbonate or any tablet excipients. Caution is also advised for patients with existing severe gastrointestinal obstruction, severe constipation, or those who cannot safely discontinue calcium‑based phosphate binders without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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