Product image of Lanthanum Orifarm (Lanthanum) supplied by GNH India

Lanthanum Orifarm

Active Ingredient:
Lanthanum
Origin:
EU

Lanthanum Orifarm (Lanthanum)

Lanthanum, the active ingredient in Lanthanum Orifarm, is a phosphate binder presented as an oral tablet for oral use. It reduces serum phosphate levels in patients with chronic kidney disease, particularly those undergoing dialysis, and is used to manage hyperphosphatemia and help control mineral‑bone disorder associated with renal impairment.

GNH India supplies Lanthanum Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, dialysis units and pharmacies worldwide, adhering to stringent quality standards and providing regulatory documentation for global distribution.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Lanthanum Orifarm is used as a phosphate‑binding agent to control elevated serum phosphate in renal‑related disorders.

  • Chronic kidney disease with hyperphosphatemia: lowers serum phosphate to target levels.
  • End‑stage renal disease on dialysis: reduces phosphate accumulation and assists in mineral balance.
  • Secondary hyperparathyroidism associated with CKD: helps control phosphate load contributing to parathyroid hormone regulation.

How It Works

  • Lanthanum carbonate dissociates in the acidic environment of the stomach, releasing lanthanum ions that bind dietary phosphate to form insoluble lanthanum phosphate complexes. These complexes are not absorbed and are eliminated in the feces, thereby decreasing the amount of phosphate absorbed from the gastrointestinal tract and lowering serum phosphate concentrations. The binding capacity is high, allowing effective phosphate reduction with relatively low tablet burden, and the complex remains stable throughout intestinal transit.

Side Effects

Lanthanum Orifarm may be associated with gastrointestinal and systemic adverse reactions.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Constipation: reduced bowel movements.
  • Diarrhea: loose stools.
  • Abdominal pain: discomfort in the stomach area.

Serious or Rare Side Effects

  • Severe constipation or intestinal obstruction: may require medical intervention.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Elevated liver enzymes: abnormal hepatic function tests.

Precautions & Warnings

When prescribing Lanthanum Orifarm, clinicians should consider the following precautions.

  • Monitor serum phosphate: adjust dose to maintain target range.
  • Assess calcium balance: avoid hypercalcemia when combined with calcium‑based binders.
  • Evaluate gastrointestinal health: caution in patients with chronic constipation or bowel disorders.
  • Review concomitant medications: antacids or iron supplements may reduce efficacy.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Lanthanum Orifarm can interact with several medicines that affect its phosphate‑binding capacity or gastrointestinal absorption.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: significantly reduce lanthanum binding.
  • Iron supplements (ferrous sulfate): decrease phosphate binding efficiency.
  • Calcium carbonate or calcium acetate: compete for binding sites, lowering effectiveness.

Moderate Interactions (Monitor Closely)

  • Vitamin D analogues (calcitriol, alfacalcidol): may alter calcium‑phosphate balance.
  • Sevelamer: additive phosphate‑binding effect, monitor serum levels.
  • Proton pump inhibitors: may affect gastric pH and lanthanum ion release.

Frequently Asked Questions

Lanthanum Orifarm is a phosphate‑binding medication used to lower elevated serum phosphate levels in patients with chronic kidney disease, especially those on dialysis. By binding dietary phosphate in the gut, it helps manage hyperphosphatemia and supports control of mineral‑bone disorders associated with renal impairment.

Lanthanum carbonate releases lanthanum ions in the acidic stomach environment. These ions bind dietary phosphate to form insoluble lanthanum phosphate complexes that are not absorbed. The complexes are excreted in the feces, reducing the amount of phosphate entering the bloodstream and thereby lowering serum phosphate concentrations.

The dose of Lanthanum Orifarm is individualized by the prescribing clinician based on the patient’s serum phosphate levels, dietary intake, and renal function. Typical regimens involve multiple tablets taken with meals, but the exact amount and frequency must be determined by a qualified healthcare professional.

Safety data for lanthanum in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To order Lanthanum Orifarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lanthanum Orifarm offers a high phosphate‑binding capacity with a relatively low tablet burden compared with calcium‑based binders, which can increase calcium load. Compared with sevelamer, lanthanum does not contain aluminum or magnesium and may have a different side‑effect profile, but both require monitoring of serum phosphate and potential gastrointestinal effects.

Store Lanthanum Orifarm tablets at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.

Lanthanum Orifarm is taken orally as a tablet with meals. The tablets should be swallowed whole with a full glass of water and should not be crushed or chewed. To avoid reduced efficacy, separate its administration from antacids, iron, or calcium supplements by at least two hours.

The most serious risks include severe constipation that can progress to intestinal obstruction, allergic reactions ranging from rash to anaphylaxis, and rare elevations in liver enzymes. Patients should be instructed to report persistent abdominal pain, vomiting, or signs of an allergic response promptly.

Lanthanum Orifarm should be avoided in individuals with known hypersensitivity to lanthanum or any component of the formulation, in patients with severe gastrointestinal obstruction, and in those who cannot safely separate its intake from interacting medications such as aluminum‑ or magnesium‑containing antacids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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