Product image of Lantus (Insulin Glargine) supplied by GNH India

Lantus

Active Ingredient:
Insulin Glargine
Origin:
EU

Lantus (Insulin Glargine)

Insulin glargine, the active ingredient in Lantus, is a long‑acting insulin presented as an injection solution for subcutaneous use. It provides basal insulin coverage to help control blood glucose levels in adults and children with type 1 or type 2 diabetes mellitus.

GNH India supplies Lantus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance, and reliable cold‑chain logistics for this biologic product.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

  • Lantus (insulin glargine) is a long‑acting insulin used to manage basal glucose control in diabetes.
  • Type 1 diabetes mellitus: provides basal insulin to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: supplies steady insulin to improve overall glycemic control when oral agents are insufficient.

How It Works

  • Insulin glargine binds to insulin receptors on peripheral tissues, stimulating glucose uptake in muscle and adipose tissue while suppressing hepatic glucose production. Its altered amino‑acid sequence reduces solubility at physiological pH, forming microprecipitates after subcutaneous injection that release insulin slowly, resulting in a prolonged, peak‑less basal effect lasting up to 24 hours.

Side Effects

Lantus may cause a range of adverse reactions.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase associated with improved glycemic control.
  • Edema: mild fluid retention in extremities.
  • Headache: occasional mild to moderate headache.
  • Lipodystrophy: localized changes in fat tissue at injection sites.

Serious or Rare Side Effects

  • Severe hypoglycemia: profound low glucose requiring assistance.
  • Anaphylactic reaction: rare but potentially life‑threatening allergy.
  • Insulin allergy: systemic rash, urticaria, or angioedema.
  • Serum insulin antibodies: may alter insulin action.
  • Acute metabolic acidosis: rare metabolic disturbance.

Precautions & Warnings

  • When using Lantus, consider the following precautions.
  • Dose adjustment: individualize based on regular blood glucose monitoring.
  • Hypoglycemia risk: educate patients to recognize and treat low glucose promptly.
  • Renal impairment: monitor kidney function and adjust dose if needed.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Alcohol consumption: may potentiate hypoglycemia, advise moderation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lantus can interact with several medicines.

Major Interactions (Avoid)

  • Concurrent rapid‑acting insulin: increased risk of severe hypoglycemia.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Sulfonylureas or meglitinides: additive glucose‑lowering effect, risk of hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may raise blood glucose, requiring dose adjustment.
  • Thiazide diuretics: can increase glucose levels.
  • ACE inhibitors: may enhance insulin sensitivity, monitor glucose.

Frequently Asked Questions

Lantus is a brand of insulin glargine, a long‑acting basal insulin used to provide continuous glucose control in patients with type 1 or type 2 diabetes mellitus. It helps maintain stable blood‑sugar levels between meals and overnight.

Insulin glargine binds to insulin receptors, promoting glucose uptake in muscle and fat cells while suppressing hepatic glucose production. After subcutaneous injection it forms microprecipitates that release insulin slowly, giving a steady, peak‑less effect for up to 24 hours.

The dose of Lantus is individualized and set by the prescribing healthcare professional based on the patient’s blood‑glucose readings, body weight, diet, and other therapies. Patients should follow the prescriber’s instructions and adjust only under medical guidance.

Safety data for insulin glargine in pregnancy and lactation are limited. It may be used when the expected benefit to the mother outweighs potential risks to the fetus or infant. Decisions should be made by the treating physician in consultation with the patient.

To order Lantus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics), and import documentation.

Lantus (insulin glargine) offers a 24‑hour, peak‑less profile similar to other basal insulins such as insulin detemir or degludec. Compared with detemir, glargine often requires once‑daily dosing, whereas detemir may need twice‑daily dosing in some patients. Choice depends on individual response, dosing convenience, and clinician preference.

Lantus should be stored in a refrigerator at 2‑8 °C. Keep the vial in its original carton, protect it from light, and do not freeze or shake the solution. Once in use, the vial may be kept at room temperature (up to 30 °C) for up to 28 days, but any cloudiness or particles indicate it should be discarded.

Lantus is given as a subcutaneous injection, typically in the abdomen, thigh, or upper arm. The injection should be performed using a sterile needle, rotating sites to avoid lipodystrophy. It is usually administered once daily at the same time each day, but the exact schedule is determined by the prescriber.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Patients should be educated to recognize early signs of low blood glucose and to seek immediate medical attention for any signs of a severe allergic response.

Lantus is contraindicated in individuals with a known hypersensitivity to insulin glargine or any of its excipients. Patients who have experienced severe allergic reactions to other insulin preparations should also avoid its use until evaluated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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