Product image of Lantus Solostar (Insulin Glargine) supplied by GNH India

Lantus Solostar

Active Ingredient:
Insulin Glargine
Origin:
EU

Lantus Solostar (Insulin Glargine)

Insulin glargine, the active ingredient in Lantus Solostar, is a long‑acting insulin analog presented as a solution for subcutaneous injection (pre‑filled pen) for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.

GNH India supplies Lantus Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams across multiple continents worldwide, ensuring consistent quality, regulatory compliance and adherence to EU pharmacopeia standards.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insulin glargine is a basal insulin analog used to manage blood glucose in diabetes.

  • Type 1 diabetes mellitus: provides basal insulin coverage to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: complements mealtime insulin or oral agents to achieve overall glycemic control.
  • Patients requiring basal insulin therapy: offers a steady, peak‑free insulin level for up to 24 hours.

How It Works

  • Insulin glargine binds to insulin receptors on muscle and adipose tissue, stimulating glucose uptake and inhibiting hepatic glucose production. Its modified amino‑acid sequence results in slow dissolution from the subcutaneous depot, delivering a prolonged, peak‑free basal insulin effect that lasts approximately 24 hours after a single injection.

Side Effects

Common Side Effects

  • Hypoglycemia: low blood glucose levels, especially if meals are missed.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: gradual increase in body weight with chronic use.
  • Edema: mild fluid retention, often in the lower extremities.
  • Lipodystrophy: localized changes in fat tissue at injection sites.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Severe hypoglycemia: can lead to loss of consciousness or seizures.
  • Anaphylactic reaction: rare but potentially life‑threatening allergic response.
  • Hypokalemia: low potassium levels, especially with high insulin doses.
  • Severe edema: significant fluid accumulation requiring medical attention.
  • Insulin antibodies: formation of antibodies that may alter insulin action.
  • Angio‑edema: swelling of deeper skin layers, potentially affecting airway.

Precautions & Warnings

When using Lantus Solostar, consider the following precautions:

  • Dose titration: adjust based on fasting glucose and HbA1c under medical supervision.
  • Hypoglycemia risk: monitor blood glucose regularly to detect low levels early.
  • Renal impairment: use caution; reduced kidney function may require dose modification.
  • Pregnancy and lactation: prescribe only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insulin glargine may interact with several medications.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: increased risk of severe hypoglycemia.
  • Beta‑blockers: may mask typical hypoglycemia symptoms.
  • Systemic corticosteroids: can diminish insulin effectiveness.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance insulin sensitivity, requiring dose review.
  • Thiazide diuretics: can raise blood glucose levels.
  • Alcohol: may cause unpredictable fluctuations in glucose control.

Frequently Asked Questions

Lantus Solostar is a pre‑filled insulin pen containing insulin glargine, a long‑acting basal insulin analog indicated for the management of blood glucose in adults and children with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus, usually as part of a comprehensive diabetes treatment regimen.

Insulin glargine provides a steady, peak‑free level of insulin after subcutaneous injection by binding to insulin receptors on muscle and adipose tissue, promoting glucose uptake, and suppressing hepatic glucose production. Its altered amino‑acid sequence results in slow dissolution from the injection site, delivering basal insulin coverage for up to 24 hours.

The dose of Lantus Solostar is individualized; a qualified prescriber determines the starting amount and any subsequent adjustments based on the patient’s fasting glucose, HbA1c, body weight, renal function, and overall treatment plan. Dosing is typically expressed in units per day and administered once daily.

Safety data for insulin glargine in pregnancy and lactation are limited. It may be used when the expected benefit to the mother outweighs potential risks to the fetus or infant, and only under close medical supervision. Healthcare providers should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lantus Solostar. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details, and necessary import documentation.

Lantus Solostar (insulin glargine) offers a 24‑hour, peak‑free basal insulin profile, similar to other long‑acting analogs such as insulin detemir or degludec. Compared with NPH insulin, it provides more predictable glucose control and a lower risk of nocturnal hypoglycemia, though individual response and cost considerations may influence the choice of therapy.

Lantus Solostar pens should be stored in a refrigerator at 2‑8 °C, protected from light, and must not be frozen or shaken. Once in use, the pen may be kept at controlled room temperature (up to 30 °C) for up to 28 days, after which it should be discarded. Always keep the pen in its original packaging.

Lantus Solostar is a pre‑filled pen designed for subcutaneous injection. The pen is primed according to the manufacturer’s instructions, the dose is set by turning the dose selector, and the injection is given into the abdomen, thigh, or upper arm at a 90° angle. The dose is typically administered once daily at the same time each day.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and rare allergic reactions such as anaphylaxis or angio‑edema. Patients should be educated to recognize early signs of hypoglycemia, monitor blood glucose regularly, and seek immediate medical attention if they experience symptoms of a severe allergic response.

Lantus Solostar is contraindicated in individuals with a known hypersensitivity to insulin glargine or any of the pen’s excipients. It should also be avoided in patients with severe hypoglycemia unawareness or those who cannot reliably monitor blood glucose. Use in patients with uncontrolled infections or acute illness should be carefully evaluated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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