Product image of Lanzafen (Olanzapine) supplied by GNH India

Lanzafen

Active Ingredient:
Olanzapine
Origin:
EU

Lanzafen (Olanzapine)

Olanzapine, the active ingredient in Lanzafen, is an atypical antipsychotic presented as an oral tablet for oral use. It is prescribed for the management of schizophrenia and bipolar disorder in adult patients, helping to control psychotic symptoms and mood swings.

GNH India supplies Lanzafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Novendia Pharmaceuticals Ltd

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Indications & Clinical Uses

  • Lanzafen (olanzapine) acts on dopamine and serotonin pathways to treat serious psychiatric conditions.
  • Schizophrenia: reduces positive and negative symptoms and improves overall functioning.
  • Bipolar I disorder (manic episodes): controls acute mania and stabilises mood.
  • Bipolar disorder maintenance: helps prevent recurrence of manic or depressive episodes.

How It Works

  • Olanzapine antagonises dopamine D2 and serotonin 5‑HT2A receptors, with additional activity at histamine H1, muscarinic, and adrenergic receptors. This receptor profile modulates neurotransmission in brain circuits involved in mood, perception, and cognition, thereby reducing psychotic and mood‑stabilising symptoms.

Side Effects

Common Side Effects

  • Weight gain: increased appetite leading to gradual weight increase.
  • Sedation: drowsiness or feeling unusually tired.
  • Dry mouth: reduced salivation causing discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headedness, especially when standing.
  • Increased appetite: heightened desire for food.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis or leukopenia: severe reduction in white blood cells.
  • Tardive dyskinesia: involuntary, repetitive movements.
  • Severe hyperglycaemia: marked increase in blood glucose levels.
  • Seizures: risk of convulsive episodes.
  • Cardiac arrhythmias: abnormal heart rhythms.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor metabolic parameters: regularly check weight, glucose, and lipid levels.
  • Assess cardiovascular risk: evaluate blood pressure and heart function.
  • Screen for seizure history: avoid use in patients with uncontrolled epilepsy.
  • Use caution in elderly with dementia: increased mortality risk has been reported.
  • Avoid abrupt discontinuation: taper gradually to reduce withdrawal effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Olanzapine may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, reducing olanzapine levels.
  • Fluvoxamine: inhibits metabolism, increasing olanzapine exposure.
  • Smoking: induces CYP1A2, lowering drug concentrations.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • Lithium: potential for increased neurotoxicity.
  • Anticholinergics: heightened anticholinergic side‑effects.

Frequently Asked Questions

Lanzafen contains olanzapine and is used to treat schizophrenia and bipolar disorder in adults. It helps reduce psychotic symptoms such as hallucinations and delusions, and stabilises mood swings during manic or depressive episodes.

Olanzapine works by blocking dopamine D2 and serotonin 5‑HT2A receptors in the brain, which moderates neurotransmitter activity linked to psychosis and mood regulation. This receptor antagonism helps improve thought processes, perception, and emotional stability.

The dose of Lanzafen is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to clinical guidelines and the patient’s specific therapeutic needs.

Safety data for olanzapine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs possible risks to the fetus or infant, and decisions are made in consultation with a healthcare professional.

To order Lanzafen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both Lanzafen (olanzapine) and risperidone are atypical antipsychotics, but olanzapine tends to have a higher propensity for metabolic side effects such as weight gain, while risperidone may cause more prolactin elevation. Choice depends on patient profile, efficacy, and tolerability considerations.

Lanzafen tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Lanzafen is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare provider.

Serious risks include neuroleptic malignant syndrome, severe hyperglycaemia, agranulocytosis, and tardive dyskinesia. Patients should be monitored for fever, muscle rigidity, rapid changes in blood glucose, signs of infection, or involuntary movements, and seek immediate medical attention if they occur.

Lanzafen should not be used by individuals with known hypersensitivity to olanzapine or any tablet excipients, those with severe central nervous system depression, or patients with uncontrolled narrow‑angle glaucoma. Caution is also advised in patients with a history of cardiovascular disease or metabolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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