Product image of Lanzul (Lansoprazole) supplied by GNH India

Lanzul

Active Ingredient:
Lansoprazole
Origin:
EU

Lanzul (Lansoprazole)

Lansoprazole, the active ingredient in Lanzul, is a proton pump inhibitor presented as an oral dosage form for oral administration. It works by decreasing gastric acid production and is prescribed for the treatment and management of gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease, and as part of Helicobacter pylori eradication regimens in adult and pediatric patients where appropriate.

GNH India supplies Lanzul as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Lansoprazole is a proton pump inhibitor used to reduce gastric acid production in several gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): provides relief of heartburn and promotes healing of esophageal irritation.
  • Erosive esophagitis: accelerates healing of erosive lesions in the esophagus.
  • Peptic ulcer disease: facilitates ulcer healing and helps prevent recurrence.
  • Helicobacter pylori eradication (as part of combination therapy): improves eradication success when used with antibiotics.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of gastric parietal cells. By blocking this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, leading to increased gastric pH. The inhibition persists until new proton pumps are synthesized, providing prolonged acid suppression over 24 hours.

Side Effects

Lansoprazole may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Constipation
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis or angioedema
  • Clostridioides difficile‑associated diarrhea
  • Low magnesium levels (hypomagnesemia) with prolonged use
  • Increased risk of fractures (hip, wrist, spine)
  • Interstitial nephritis
  • Hepatic dysfunction including hepatitis

Precautions & Warnings

Before prescribing Lanzul, clinicians should consider several safety measures.

  • Assess renal and hepatic function: adjust use in patients with severe impairment.
  • Monitor magnesium levels: prolonged therapy may lead to hypomagnesemia.
  • Avoid concomitant use with drugs that require gastric acidity for absorption, as efficacy may be reduced.
  • Use with caution in elderly patients due to an increased fracture risk.
  • Store at ambient temperature (below 25°C): keep in the original container, protect from moisture and light.

Avoid Interactions

Lansoprazole can interact with a variety of medicines, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir or other protease inhibitors: decreased antiviral absorption.
  • Methotrexate: increased toxicity due to reduced renal clearance.
  • Warfarin: potential increase in INR and bleeding risk.
  • Ketoconazole: decreased antifungal absorption.

Moderate Interactions (Monitor Closely)

  • Digoxin: may increase serum concentrations.
  • Diazepam: enhanced sedation.
  • Iron salts: reduced iron absorption.
  • Vitamin B12: long‑term use may impair absorption.

Frequently Asked Questions

Lanzul contains lansoprazole, a proton pump inhibitor indicated for the treatment of gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease, and as part of combination therapy for Helicobacter pylori eradication. It reduces gastric acid secretion, helping to relieve symptoms and promote healing of acid‑related lesions in the gastrointestinal tract.

Lansoprazole works by selectively and irreversibly blocking the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition stops the final step of acid production, leading to a sustained increase in gastric pH and reduced acidity throughout the stomach.

The specific dose of Lanzul is determined by the prescribing clinician based on the patient’s condition, age, and response to therapy. Typical dosing regimens for adults range from 15 mg to 30 mg once daily, but the exact regimen should always follow the prescriber’s instructions and local labeling.

Safety data for lansoprazole during pregnancy and lactation are limited. It is generally classified as a drug that should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as small amounts may be excreted in milk.

To order Lanzul, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and any necessary import documentation.

Lanzul (lansoprazole) and omeprazole belong to the same class of proton pump inhibitors and share a similar mechanism of reducing gastric acid. Lansoprazole may have a slightly longer duration of action and is often preferred in certain eradication regimens, while omeprazole is widely available and may be chosen based on cost or formulary preferences.

Lanzul should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in areas with high humidity or direct sunlight.

Lanzul is taken orally, usually as a whole tablet swallowed with a glass of water. It can be taken with or without food, but consistency in timing relative to meals helps maintain stable drug levels. Patients should follow the prescriber’s instructions regarding frequency and duration of therapy.

Serious risks, though uncommon, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, hypomagnesemia with long‑term use, increased fracture risk in the elderly, interstitial nephritis, and hepatic dysfunction. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, persistent diarrhea, or unexplained bone pain.

Lanzul should be avoided in individuals with known hypersensitivity to lansoprazole or any other proton pump inhibitor. Caution is also advised for patients with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with a history of fractures or osteoporosis unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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