Product image of Lanzul S (Lansoprazole) supplied by GNH India

Lanzul S

Active Ingredient:
Lansoprazole
Origin:
EU

Lanzul S (Lansoprazole)

Lansoprazole, the active ingredient in Lanzul S, is a proton pump inhibitor presented as an oral dosage form for systemic use. It reduces gastric acid secretion and is employed in the management of acid‑related gastrointestinal disorders in adults.
GNH India supplies Lanzul S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka-Farma D.O.O.

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Indications & Clinical Uses

Lansoprazole is indicated for conditions involving excess gastric acid production.

  • Gastro‑esophageal reflux disease (GERD): alleviates heartburn and esophageal irritation by lowering stomach acidity.
  • Duodenal ulcer: promotes healing of ulcer lesions through sustained acid suppression.
  • Helicobacter pylori eradication regimens: enhances antibiotic effectiveness by creating a less acidic gastric environment.
  • Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid associated with gastrin‑producing tumors.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, leading to an increased gastric pH and facilitating mucosal healing.

Side Effects

Lansoprazole may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate pain often resolving without intervention.
  • Diarrhea: loose stools that may improve with continued therapy.
  • Nausea: occasional feeling of queasiness, typically mild.
  • Abdominal pain: discomfort in the stomach area, usually transient.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis presenting with watery diarrhea.
  • Acute interstitial nephritis: kidney inflammation that may cause reduced urine output.
  • Hypersensitivity reactions: rash, angioedema, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal and hepatic function: dose adjustment may be needed in impairment.
  • Evaluate for CYP2C19 polymorphisms: altered metabolism can affect drug levels.
  • Monitor long‑term use: prolonged therapy may increase risk of bone fractures.
  • Review concomitant medications: potential for reduced absorption of drugs requiring acidic pH.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Lansoprazole can affect the pharmacokinetics of several co‑administered agents.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption leading to therapeutic failure.
  • Atazanavir: markedly decreased antiviral exposure, compromising HIV treatment.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, requiring closer coagulation monitoring.
  • Methotrexate: elevated serum levels may occur, especially at high doses.
  • Digoxin: modest increase in plasma concentration, warranting dose review.

Frequently Asked Questions

Lanzul S contains lansoprazole, which is prescribed to treat acid‑related gastrointestinal disorders such as gastro‑esophageal reflux disease, duodenal ulcers, Helicobacter pylori eradication regimens, and Zollinger‑Ellison syndrome. It works by reducing stomach acid production, helping to relieve symptoms and promote healing of the gastrointestinal lining.

Lansoprazole belongs to the proton pump inhibitor class. It binds irreversibly to the H+/K+ ATPase enzyme on gastric parietal cells, blocking the final step of acid secretion. This inhibition raises gastric pH, decreasing acidity and allowing damaged tissue in the stomach and esophagus to heal.

The appropriate dose of Lanzul S is determined by the prescribing healthcare professional based on the specific indication, patient age, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for lansoprazole in pregnancy and lactation are limited. The prescriber will weigh potential benefits against possible risks before recommending use. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss their situation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lanzul S. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Lansoprazole, as a proton pump inhibitor, provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, its pharmacokinetic profile and CYP2C19 metabolism may differ, influencing drug‑drug interaction potential and individual response.

Lanzul S should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Lanzul S is taken orally, usually with a glass of water. It can be administered with or without food, but consistency with regard to meals is advisable to maintain stable drug absorption. Patients should swallow the tablet whole and not crush or chew it unless directed otherwise.

Serious adverse events, though uncommon, include Clostridioides difficile‑associated diarrhea, acute interstitial nephritis, and severe hypersensitivity reactions such as rash, angioedema, or anaphylaxis. Patients should seek immediate medical attention if they experience persistent diarrhea, unexplained kidney problems, or signs of an allergic reaction.

Lanzul S is contraindicated in individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is advised for patients with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with a history of certain infections or bone disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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