Product image of Lapio Duo (Timolol Maleate, Latanoprost) supplied by GNH India

Lapio Duo

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Lapio Duo (Timolol Maleate, Latanoprost)

Timolol Maleate and Latanoprost, the active ingredients in Lapio Duo, are a beta‑blocker and a prostaglandin analog presented as eye drops for ocular use. They lower intra‑ocular pressure in patients with primary open‑angle glaucoma or ocular hypertension, helping to prevent optic nerve damage and visual field loss.

GNH India supplies Lapio Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions.

Manufacturer / TM Owner

Bruschettini S.R.L

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Indications & Clinical Uses

  • Lapio Duo is indicated for ocular conditions where reduction of intra‑ocular pressure is required.
  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to prevent optic nerve damage and visual field loss.
  • Ocular hypertension: lowers intra‑ocular pressure to reduce the risk of progression to glaucoma.
  • Post‑operative ocular pressure spikes: helps control transient pressure elevation after eye surgery.

How It Works

  • Timolol maleate non‑selectively blocks beta‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. Latanoprost, a prostaglandin F2α analog, binds to FP receptors, enhancing uveoscleral outflow of aqueous humor. The combined actions result in a greater reduction of intra‑ocular pressure than either component alone.

Side Effects

Common Side Effects

  • Blurred vision
  • Eye irritation or burning sensation
  • Conjunctival hyperemia (redness)
  • Increased eyelash growth
  • Dry eye sensation
  • Mild pruritus

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis)
  • Persistent eye pain or photophobia
  • Corneal edema or ulceration
  • Sudden loss of vision
  • Intra‑ocular inflammation
  • Systemic bradycardia or hypotension

Precautions & Warnings

Before initiating therapy, evaluate patient medical history and concomitant medications.

  • Cardiovascular assessment: monitor patients with bradycardia, heart block, or heart failure.
  • Respiratory caution: avoid in patients with asthma or chronic obstructive pulmonary disease.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Ocular surgery: discontinue prior to intra‑ocular procedures to reduce risk of delayed wound healing.
  • Store at room temperature: keep bottle tightly closed, protect from light and moisture.

Avoid Interactions

Major Interactions (Avoid)

  • Systemic beta‑blockers: may cause additive bradycardia or hypotension.
  • Other prostaglandin analog eye drops: may increase risk of ocular inflammation.
  • Sympathomimetic agents: can reduce the ocular hypotensive effect of timolol.

Moderate Interactions (Monitor Closely):\n- Carbonic anhydrase inhibitors: may produce excessive intra‑ocular pressure reduction.

  • Anticholinergic eye drops: may diminish the efficacy of timolol.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for increased ocular irritation.

Frequently Asked Questions

Lapio Duo is prescribed to lower intra‑ocular pressure in patients with primary open‑angle glaucoma and ocular hypertension, helping to prevent optic nerve damage and preserve visual field.

Timolol maleate blocks beta‑adrenergic receptors, reducing aqueous humor production, while latanoprost, a prostaglandin F2α analogue, increases uveoscleral outflow. Together they provide a synergistic reduction in intra‑ocular pressure.

The dosing regimen for Lapio Duo is determined by the prescribing ophthalmologist based on the individual patient's condition, response, and tolerance. Patients should follow the specific instructions provided by their healthcare professional.

The safety of Lapio Duo in pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To request Lapio Duo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

When used as separate monotherapies, timolol reduces aqueous production and latanoprost enhances outflow. The combination in Lapio Duo offers a broader mechanism of action, often achieving greater intra‑ocular pressure reduction than either agent alone, which can be advantageous for patients needing stronger control.

Lapio Duo should be stored at room temperature, below 25 °C, in the original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.

Lapio Duo is applied as an ophthalmic solution. The patient instills the prescribed number of drops into the affected eye(s) using the provided dropper, typically once daily in the evening, unless otherwise directed by the prescriber.

Serious risks include severe allergic reactions, significant eye pain, sudden loss of vision, corneal edema, and systemic effects such as bradycardia or hypotension, especially in patients with pre‑existing cardiovascular conditions.

Lapio Duo is contraindicated in patients with known hypersensitivity to timolol, latanoprost, or any excipients, and should be avoided in individuals with severe sinus node dysfunction, uncontrolled asthma, or acute bronchospasm without careful medical evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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