Product image of Lapixen (Lacidipine) supplied by GNH India

Lapixen

Active Ingredient:
Lacidipine
Origin:
EU

Lapixen (Lacidipine)

Lacidipine, the active ingredient in Lapixen, is a calcium channel blocker presented as an oral tablet for oral use. It lowers elevated blood pressure in adults with essential hypertension by selectively inhibiting L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced systemic vascular resistance.

GNH India supplies Lapixen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution efficiently.

Manufacturer / TM Owner

Biofarm Sp. Z O.O.

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Indications & Clinical Uses

Lacidipine is indicated for the treatment of hypertension, a condition characterized by chronically elevated arterial pressure.

  • Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension.
  • Isolated systolic hypertension: provides blood pressure control in older patients with predominantly elevated systolic pressure.

How It Works

  • Lacidipine selectively blocks L-type calcium channels located on vascular smooth‑muscle cells. This inhibition prevents calcium influx, causing relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lacidipine may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: sensation of light‑headedness, especially on standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: rapid swelling of face, lips, tongue, or throat.
  • Hepatic dysfunction: abnormal liver enzyme elevations or hepatitis.

Precautions & Warnings

When prescribing lacidipine, clinicians should observe several precautionary measures to ensure patient safety.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Liver function: evaluate hepatic enzymes before initiating therapy.
  • Elderly patients: start at lower dose and monitor for dizziness.
  • Concomitant antihypertensives: adjust doses to prevent additive effects.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Lacidipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacidipine plasma levels, risking hypotension.
  • Grapefruit juice: can raise drug concentration, leading to excessive blood pressure drop.
  • Other potent antihypertensives (e.g., beta‑blockers, ACE inhibitors): may cause additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce lacidipine effectiveness.
  • Digoxin: lacidipine may increase digoxin levels, requiring serum monitoring.

Frequently Asked Questions

Lapixen contains the active ingredient lacidipine and is prescribed to treat hypertension. By lowering elevated systolic and diastolic blood pressure, it helps reduce the risk of cardiovascular complications associated with chronic high blood pressure.

Lacidipine selectively blocks L-type calcium channels in the smooth muscle of blood vessels. This blockade prevents calcium entry, causing the vessels to relax and widen (vasodilation), which decreases peripheral resistance and ultimately lowers arterial blood pressure.

The appropriate dose of Lapixen is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lacidipine in pregnancy and lactation are limited. It is generally recommended to avoid use unless the potential benefit justifies the possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To request Lapixen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacidipine belongs to the dihydropyridine class of calcium channel blockers, offering potent vasodilation with a relatively long half‑life. Compared with agents such as amlodipine, it may provide a smoother blood‑pressure profile but shares similar side‑effect patterns. Choice of therapy depends on patient‑specific factors and physician judgment.

Lapixen tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Lapixen is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, angioedema, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or signs of liver dysfunction such as jaundice.

Lacidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. Caution is advised for individuals with severe aortic stenosis, unstable angina, or those taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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