Product image of Laresin Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Laresin Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Laresin Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil and hydrochlorothiazide, the active ingredients in Laresin Plus, are an angiotensin II receptor blocker and a thiazide diuretic presented as oral tablets for systemic use. They treat hypertension in adult patients by lowering elevated blood pressure through complementary mechanisms that reduce vascular resistance and plasma volume.

GNH India supplies Laresin Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines across global markets.

Manufacturer / TM Owner

Berlin-Chemie Ag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Laresin Plus combines an angiotensin II receptor blocker with a thiazide diuretic to manage hypertension.
  • Essential hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Renal hypertension: assists in blood pressure control in patients whose hypertension is secondary to renal disease.
  • Diastolic hypertension: helps achieve target diastolic pressure in patients with elevated diastolic readings.

How It Works

  • Olmesartan medoxomil selectively blocks the AT1 receptor, preventing angiotensin II‑mediated vasoconstriction, aldosterone release, and sodium retention. Hydrochlorothiazide inhibits NaCl reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume. The combined actions lower systemic vascular resistance and reduce circulating fluid, resulting in a net reduction of arterial blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Increased urinary frequency
  • Mild electrolyte changes (e.g., low potassium)
  • Dry mouth or mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis
  • Angioedema (swelling of face, lips, tongue)
  • Significant electrolyte disturbances such as hyperkalemia or hyponatremia
  • Acute renal impairment or sudden rise in serum creatinine
  • Pancreatitis
  • Marked hypotension leading to fainting

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Renal function: assess kidney function and monitor creatinine regularly.
  • Electrolytes: check serum potassium and sodium levels periodically.
  • Pregnancy: avoid use unless the potential benefit justifies the risk.
  • Elderly patients: start at a lower dose and monitor for orthostatic hypotension.
  • Drug interactions: review all concomitant medicines for possible interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Laresin Plus may interact with several medicines; monitor as indicated.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or potassium supplements: risk of hyperkalemia.
  • ACE inhibitors or other ARBs: additive blood‑pressure lowering and possible renal impairment.
  • Lithium: increased lithium concentrations and toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance hypotensive effect.
  • Calcium channel blockers: additive blood‑pressure reduction.
  • Antidiabetic agents: blood‑glucose levels may change, requiring dose adjustment.

Frequently Asked Questions

Laresin Plus is prescribed to lower high blood pressure in adult patients. It combines an angiotensin II receptor blocker with a thiazide diuretic, providing complementary actions that reduce vascular resistance and plasma volume, helping achieve target blood‑pressure goals in essential and secondary hypertension.

Olmesartan medoxomil blocks the AT1 subtype of angiotensin II receptors. By preventing angiotensin II from binding, it inhibits vasoconstriction, aldosterone release, and sodium retention, leading to relaxed blood vessels and reduced fluid overload, which together lower arterial pressure.

The dose of Laresin Plus is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall health status. The prescriber determines the appropriate strength and dosing schedule; patients should follow the written prescription exactly.

The safety of Laresin Plus in pregnancy has not been established, and the product is generally avoided unless the potential benefit outweighs the risk. Limited data are available for breastfeeding; therefore, clinicians usually recommend alternative therapies for pregnant or nursing mothers.

To request Laresin Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, Laresin Plus offers dual action: an ARB for vascular relaxation and a thiazide diuretic for volume reduction. This combination often achieves blood‑pressure control more efficiently than monotherapy, while maintaining a safety profile similar to each component used alone.

Store Laresin Plus at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Laresin Plus is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Patients should be alert for signs of severe allergic reaction (rash, swelling, difficulty breathing), angioedema, marked drops in blood pressure causing dizziness or fainting, significant electrolyte disturbances (especially high potassium), and sudden worsening of kidney function. Any of these symptoms require immediate medical attention.

Laresin Plus is contraindicated in individuals with known hypersensitivity to olmesartan, hydrochlorothiazide, or any tablet components. It should also be avoided in patients with severe renal impairment, hyperkalemia, or those taking prohibited medications such as other ARBs, ACE inhibitors, or potassium‑sparing diuretics without close supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.