Product image of Largactil (Chlorpromazine Hydrochloride) supplied by GNH India

Largactil

Active Ingredient:
Chlorpromazine Hydrochloride
Origin:
EU

Largactil (Chlorpromazine Hydrochloride)

Chlorpromazine, the active ingredient in Largactil, is a phenothiazine antipsychotic presented as an oral dosage form for systemic use. It is employed in the management of schizophrenia, acute psychotic states and manic episodes, primarily in adult patients.
GNH India supplies Largactil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm France

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Indications & Clinical Uses

Chlorpromazine acts on central nervous system pathways involved in psychosis and mood regulation.

  • Schizophrenia: helps reduce hallucinations, delusions and thought disorder.
  • Acute psychosis: stabilises severe agitation and psychotic symptoms.
  • Manic episodes: moderates elevated mood, hyperactivity and irritability.

How It Works

  • Chlorpromazine exerts its antipsychotic effect mainly through antagonism of dopamine D2 receptors, decreasing dopaminergic neurotransmission in mesolimbic pathways. It also blocks histamine H1, muscarinic acetylcholine, and alpha‑adrenergic receptors, contributing to its sedative, anticholinergic and vasodilatory properties.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation causing discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Orthostatic hypotension: dizziness upon standing.
  • Weight gain: increased appetite leading to weight increase.
  • Extrapyramidal symptoms: mild tremor or rigidity.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening fever and muscle rigidity.
  • Tardive dyskinesia: persistent involuntary movements.
  • Severe hypotension: marked drop in blood pressure.
  • Agranulocytosis: dangerous reduction in white blood cells.
  • Seizures: occurrence of convulsive episodes.
  • Hepatotoxicity: liver enzyme elevations or injury.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Cardiac monitoring: assess baseline ECG in patients with cardiac risk.
  • Diabetes screening: monitor blood glucose in susceptible individuals.
  • Liver function: evaluate hepatic enzymes for patients with liver disease.
  • Elderly patients: start at low dose and watch for confusion or falls.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Chlorpromazine may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, opioids): risk of profound sedation and respiratory depression.
  • Anticholinergic agents: additive anticholinergic burden leading to severe constipation or urinary retention.
  • QT‑prolonging drugs (e.g., quinidine, haloperidol): heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase chlorpromazine plasma levels.
  • Antihypertensives: additive hypotensive effect, monitor blood pressure.
  • Alcohol: enhances sedative properties, advise limited intake.

Frequently Asked Questions

Largactil, containing chlorpromazine, is prescribed for schizophrenia, acute psychotic episodes and manic phases of bipolar disorder. It helps control hallucinations, severe agitation and mood elevation by modulating neurotransmitter activity in the brain.

Chlorpromazine blocks dopamine D2 receptors, reducing dopaminergic signaling that contributes to psychosis. It also antagonises histamine, muscarinic and alpha‑adrenergic receptors, which adds sedative, anticholinergic and vasodilatory effects that support its therapeutic action.

The dosage of Largactil is individualized by the prescribing clinician based on the patient’s condition, age, weight and response. Healthcare professionals determine the appropriate starting dose and any necessary adjustments during treatment.

Chlorpromazine should be used in pregnancy or while breastfeeding only when the potential benefit justifies the possible risk to the fetus or infant. Clinicians evaluate each case carefully and discuss alternatives when appropriate.

To request Largactil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Largactil (chlorpromazine) is a first‑generation phenothiazine antipsychotic, whereas many newer agents belong to the second‑generation (atypical) class. Compared with atypicals, chlorpromazine often has stronger anticholinergic and sedative effects but may carry a higher risk of extrapyramidal symptoms.

Largactil should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Largactil is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule, including timing and any dose adjustments, is determined by the treating clinician.

Serious risks include neuroleptic malignant syndrome, tardive dyskinesia, severe hypotension, agranulocytosis and cardiac arrhythmias such as QT prolongation. Patients should be monitored closely for any signs of these conditions, and treatment should be stopped if they occur.

Largactil is contraindicated in individuals with known hypersensitivity to chlorpromazine or any phenothiazine, those with severe bone‑marrow suppression, and patients with uncontrolled narrow‑angle glaucoma. Caution is also advised for patients with significant cardiovascular disease or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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