Largactil (Chlorpromazine Hydrochloride)

Chlorpromazine works by blocking dopamine D2 receptors in the brain, which reduces dopaminergic activity that contributes to psychotic symptoms. It also antagonizes histamine, muscarinic, and alpha‑adrenergic receptors, providing additional sedative, anticholinergic, and vasodilatory effects that support its anti‑psychotic and anti‑emetic actions.

The appropriate dose of chlorpromazine is individualized and determined by the prescribing clinician based on the patient’s condition, age, response, and tolerance. Dosage may be started low and titrated upward, and the prescriber will provide specific instructions for each patient.

Safety data for chlorpromazine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To order Largactil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Chlorpromazine belongs to the typical antipsychotic (phenothiazine) class, which primarily blocks dopamine D2 receptors. Atypical antipsychotics, such as risperidone or olanzapine, also target serotonin receptors and often have a lower risk of extrapyramidal symptoms but may carry higher metabolic side‑effect profiles. Choice depends on clinical response, side‑effect tolerance and individual patient factors.

Largactil tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Largactil is administered orally as a tablet. It should be taken with or without food as directed by the prescriber, and the patient should follow the exact dosing schedule provided on the prescription label.

Serious risks include extrapyramidal symptoms such as severe muscle rigidity or tremor, neuroleptic malignant syndrome—a rare but life‑threatening condition with high fever and muscle breakdown, and tardive dyskinesia, which may become permanent. Prompt medical attention is required if any of these symptoms develop.

Chlorpromazine should be avoided in patients with known hypersensitivity to phenothiazines, those taking monoamine oxidase inhibitors, or individuals with severe cardiovascular disease, uncontrolled glaucoma, or a history of neuroleptic malignant syndrome. It is also contraindicated in patients with significant bone marrow suppression.