Product image of Largactil Iv (Chlorpromazine Hydrochloride) supplied by GNH India

Largactil Iv

Active Ingredient:
Chlorpromazine Hydrochloride
Origin:
EU

Largactil Iv (Chlorpromazine Hydrochloride)

Chlorpromazine, the active ingredient in Largactil Iv, is a phenothiazine antipsychotic presented as an injectable solution for intravenous use. It treats schizophrenia, acute psychosis, manic episodes, severe nausea and vomiting, and provides preoperative sedation in appropriate patients.

GNH India supplies Largactil Iv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Faes Farma Portugal, S.A.

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Indications & Clinical Uses

Chlorpromazine is a phenothiazine antipsychotic that modulates dopaminergic and other neurotransmitter pathways.

  • Schizophrenia: reduces delusions, hallucinations and other psychotic symptoms.
  • Acute psychosis: stabilises severe agitation and psychotic disturbances.
  • Manic episodes: helps control elevated mood and hyperactivity.
  • Severe nausea and vomiting: provides antiemetic relief when other agents are insufficient.
  • Preoperative sedation: produces calming and anxiolytic effects before surgery.

How It Works

  • Chlorpromazine acts primarily as a dopamine D2 receptor antagonist, decreasing dopaminergic neurotransmission in the mesolimbic pathway. It also blocks serotonin (5‑HT2), histamine (H1), and adrenergic (α1) receptors, contributing to its antipsychotic, antiemetic, and sedative properties. These combined actions modulate multiple central nervous system pathways, producing therapeutic effects in psychosis, nausea, and pre‑operative anxiety.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Sedation: drowsiness or reduced alertness.
  • Orthostatic hypotension: dizziness upon standing.
  • Anticholinergic effects: dry mouth, blurred vision, constipation.
  • Weight gain: increased appetite and body weight.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Cardiac arrhythmias: QT prolongation leading to torsades de pointes.
  • Tardive dyskinesia: persistent involuntary movements of the face or limbs.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety factors.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially after the first dose.
  • Cardiac assessment: evaluate QT interval and history of arrhythmias.
  • Hepatic function: adjust use in patients with significant liver impairment.
  • Elderly patients: use cautiously due to increased risk of sedation and falls.
  • Hypersensitivity: discontinue if allergic reactions such as rash or bronchospasm occur.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Chlorpromazine may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • CNS depressants: enhanced sedation and respiratory depression.
  • Antihypertensives: additive hypotensive effects.
  • QT‑prolonging agents: increased risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise chlorpromazine plasma levels.
  • Lithium: concurrent use can increase lithium toxicity.

Frequently Asked Questions

Largactil Iv, containing chlorpromazine, is indicated for the management of schizophrenia, acute psychosis, manic episodes, severe nausea and vomiting, and for pre‑operative sedation. It is administered intravenously in hospital settings where rapid therapeutic effect is required.

Chlorpromazine blocks dopamine D2 receptors and also antagonises serotonin, histamine, and adrenergic receptors. This multi‑receptor blockade reduces psychotic symptoms, provides anti‑emetic action, and produces sedation, addressing the diverse clinical uses of the drug.

The specific dose of Largactil Iv is determined by the prescribing clinician based on the patient’s condition, severity, age, weight, and response to therapy. Healthcare professionals tailor the regimen to achieve optimal therapeutic outcomes while minimizing adverse effects.

Chlorpromazine is classified as Pregnancy Category B, indicating no evidence of fetal risk in animal studies, but adequate human data are lacking. Use during pregnancy or lactation should only occur when the potential benefit justifies any potential risk, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and necessary import documentation.

Largactil Iv (chlorpromazine) is a first‑generation, phenothiazine antipsychotic, whereas many newer agents belong to the second‑generation (atypical) class. Chlorpromazine has a broader receptor profile, leading to more pronounced anticholinergic and sedative effects, while atypicals often have lower risk of extrapyramidal symptoms but may carry metabolic side‑effects.

Largactil Iv should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use to maintain stability and sterility.

Largactil Iv is given by slow intravenous injection or infusion under medical supervision. The rate of administration is adjusted according to the clinical indication and patient tolerance, and vital signs are monitored throughout the procedure.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hypotension, cardiac arrhythmias such as QT prolongation, and tardive dyskinesia. Prompt recognition and immediate medical intervention are essential if any of these events occur.

Largactil Iv is contraindicated in patients with known hypersensitivity to chlorpromazine or any phenothiazine component, in those with severe cardiovascular disease that could be worsened by hypotension, and in individuals with a history of neuroleptic malignant syndrome. Caution is also advised for patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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