Product image of Larofen (Ibuprofen) supplied by GNH India

Larofen

Active Ingredient:
Ibuprofen
Origin:
EU

Larofen (Ibuprofen)

Ibuprofen, the active ingredient in Larofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for the relief of mild to moderate pain, fever and inflammatory conditions in adults and children when appropriate.

GNH India supplies Larofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laropharm Srl

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Indications & Clinical Uses

Ibuprofen is used to manage pain and inflammation across several common clinical conditions.

  • Headache: reduces pain and associated discomfort.
  • Musculoskeletal pain: alleviates pain and improves mobility in conditions such as sprains, strains and arthritis.
  • Fever: lowers elevated body temperature in febrile states.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which are key in the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and limits the inflammatory response in tissues.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Cardiovascular events including myocardial infarction or stroke.

Precautions & Warnings

When using ibuprofen, several safety considerations should be observed to minimise risk.

  • Assess renal function: avoid use in patients with severe renal impairment without medical supervision.
  • Monitor gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding.
  • Evaluate cardiovascular status: limit use in patients with uncontrolled hypertension or known heart disease.
  • Use during pregnancy: consult a healthcare professional; ibuprofen is generally avoided in the third trimester.
  • Drug interactions: review concomitant medications for potential interactions before initiating therapy.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with other medicines, altering their effectiveness or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • High‑dose aspirin: heightened gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for decreased renal perfusion.
  • Lithium: ibuprofen can raise serum lithium levels.
  • Methotrexate: may increase methotrexate toxicity at high doses.

Frequently Asked Questions

Larofen contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, reduce fever, and control inflammation associated with conditions such as headaches, musculoskeletal injuries, and arthritic disorders.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels decrease pain signaling, lower body temperature, and limit the inflammatory response.

The appropriate dose of Larofen is determined by a qualified prescriber based on the individual’s age, weight, medical condition, and response to therapy. Patients should follow the specific dosing instructions provided by their healthcare professional.

Ibuprofen is generally avoided during the third trimester of pregnancy because of potential risks to the fetus. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative options with their healthcare provider.

To order Larofen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Larofen (ibuprofen) shares the core anti‑inflammatory, analgesic and antipyretic properties of other NSAIDs such as naproxen or diclofenac. Compared with some longer‑acting NSAIDs, ibuprofen has a relatively short half‑life, which may allow more flexible dosing but may also require more frequent administration for sustained effect.

Larofen should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme heat to maintain its stability and potency.

Larofen is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, renal impairment, severe allergic reactions such as Stevens‑Johnson syndrome, and increased cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding, severe renal or hepatic impairment, uncontrolled hypertension, or certain cardiovascular conditions should avoid using Larofen unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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