Product image of Larofen Plus (Pseudoephedrine Hydrochloride, Ibuprofen) supplied by GNH India

Larofen Plus

Active Ingredient:
Pseudoephedrine Hydrochloride, Ibuprofen
Origin:
EU

Larofen Plus (Pseudoephedrine Hydrochloride, Ibuprofen)

Pseudoephedrine Hydrochloride, the active ingredient in Larofen Plus, is a combination decongestant and nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It helps relieve nasal congestion, headache, fever and general pain in adults and adolescents when prescribed by a healthcare professional.

GNH India supplies Larofen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laropharm Srl

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Indications & Clinical Uses

Larofen Plus combines a nasal decongestant with an NSAID, addressing conditions where inflammation and congestion coexist.

  • Nasal congestion: reduces swelling of nasal passages to improve airflow.
  • Headache: alleviates pain by decreasing prostaglandin‑mediated inflammation.
  • Fever: lowers elevated body temperature through antipyretic action.
  • General pain: provides analgesia for musculoskeletal or mild to moderate pain.

How It Works

  • Pseudoephedrine acts as an α‑adrenergic agonist, causing vasoconstriction of the nasal mucosa and reducing edema. Ibuprofen inhibits cyclooxygenase‑1 and‑2 enzymes, decreasing prostaglandin synthesis, which results in analgesic, antipyretic and anti‑inflammatory effects throughout the body.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Nausea: mild stomach upset.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or breathing difficulty.
  • Gastrointestinal bleeding: black stools or vomiting blood.
  • Hypertension: significant rise in blood pressure.

Precautions & Warnings

Before using Larofen Plus, consider the following safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart disease history.
  • Renal caution: adjust use in patients with impaired kidney function.
  • Gastro‑intestinal risk: avoid in individuals with active ulcers or bleeding disorders.
  • Drug combination warning: do not combine with other sympathomimetics or NSAIDs without medical advice.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Larofen Plus may interact with several medication classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other sympathomimetic agents: excessive vasoconstriction.
  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Additional NSAIDs: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely):\n- Antihypertensives: possible reduction in blood‑pressure control.

  • Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency.
  • Diuretics: potential for electrolyte imbalance, especially potassium.

Frequently Asked Questions

Larofen Plus is indicated for temporary relief of nasal congestion, headache, fever and mild to moderate pain. It is useful when both decongestion and anti‑inflammatory effects are needed, such as during colds, sinus pressure or musculoskeletal discomfort.

Pseudoephedrine hydrochloride stimulates α‑adrenergic receptors in the nasal mucosa, causing blood‑vessel constriction. This reduces swelling and opens the nasal passages, helping to relieve congestion and improve breathing.

The specific dose and frequency of Larofen Plus are determined by the prescribing clinician based on the patient’s age, weight, medical condition and other medications. Patients should follow the healthcare professional’s instructions and the product label.

Safety information for pregnancy and lactation is limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Larofen Plus.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Larofen Plus combines pseudoephedrine with ibuprofen, offering both vasoconstrictive decongestion and COX‑inhibition for pain and inflammation. Compared with products that pair pseudoephedrine with acetaminophen, ibuprofen provides stronger anti‑inflammatory action but may carry a higher gastrointestinal risk.

Larofen Plus should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablet container tightly closed, protect it from moisture, heat and direct sunlight to maintain product stability.

Larofen Plus is taken orally with a full glass of water. It is usually swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include severe allergic reactions (anaphylaxis), significant hypertension, gastrointestinal bleeding, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, vomiting blood or sudden high blood pressure.

Individuals with known hypersensitivity to pseudoephedrine, ibuprofen or any component of the formulation should avoid Larofen Plus. It is also contraindicated in patients with uncontrolled hypertension, severe coronary artery disease, active gastrointestinal ulceration, or those taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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