Product image of Laroxyl (Amitriptyline Hydrochloride) supplied by GNH India

Laroxyl

Active Ingredient:
Amitriptyline Hydrochloride
Origin:
EU

Laroxyl (Amitriptyline Hydrochloride)

Amitriptyline Hydrochloride, the active ingredient in Laroxyl, is a tricyclic antidepressant presented as an oral tablet for oral use. It is prescribed for major depressive disorder, chronic neuropathic pain and migraine prophylaxis in adult patients.

GNH India supplies Laroxyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

  • Laroxyl, a tricyclic antidepressant, is used to treat several conditions affecting mood and pain pathways.
  • Major depressive disorder: reduces depressive symptoms and improves mood in adults.
  • Depressive episodes: alleviates acute depressive symptoms during episodic phases.
  • Chronic neuropathic pain: lessens pain intensity and improves functional ability.
  • Migraine prophylaxis: decreases frequency and severity of migraine attacks.

How It Works

  • Amitriptyline Hydrochloride blocks the reuptake of norepinephrine and serotonin at neuronal synapses, increasing their extracellular concentrations. This enhances neurotransmission in central pathways that regulate mood, pain perception, and vascular tone, contributing to its antidepressant, analgesic, and migraine‑preventive effects.

Side Effects

Amitriptyline may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dry mouth
  • Constipation
  • Drowsiness or sedation
  • Weight gain
  • Blurred vision
  • Urinary retention

Serious or Rare Side Effects

  • Cardiac arrhythmias or conduction abnormalities
  • Seizures, especially at high doses
  • Severe hypotension or orthostatic collapse
  • Suicidal thoughts or behavior
  • Blood dyscrasias such as agranulocytosis
  • Hepatic toxicity or elevated liver enzymes

Precautions & Warnings

  • When prescribing Laroxyl, clinicians should consider several safety measures.
  • Assess cardiac history: evaluate for conduction disorders before initiation.
  • Monitor for suicidal ideation: especially during early treatment or dose changes.
  • Use cautiously in elderly: increased sensitivity to anticholinergic effects.
  • Avoid abrupt discontinuation: taper gradually to reduce withdrawal symptoms.
  • Adjust dose in hepatic impairment: reduce dosage as needed.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Amitriptyline can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
  • Selective serotonin reuptake inhibitors (SSRIs) or other serotonergic agents: increased serotonin toxicity.
  • Alcohol or CNS depressants: enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: additive blood pressure lowering.
  • Antidiabetic agents: potential hypoglycemia.
  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): may raise amitriptyline plasma levels.

Frequently Asked Questions

Laroxyl, containing amitriptyline hydrochloride, is indicated for major depressive disorder, depressive episodes, chronic neuropathic pain, and migraine prophylaxis. It helps improve mood, reduce pain sensations, and lower the frequency of migraine attacks when prescribed by a qualified healthcare professional.

Amitriptyline hydrochloride inhibits the reuptake of the neurotransmitters norepinephrine and serotonin at synaptic junctions, raising their levels in the central nervous system. This modulation enhances mood regulation, diminishes pain signaling, and stabilizes vascular tone, which underlies its antidepressant, analgesic, and migraine‑preventive actions.

The dosage of Laroxyl is individualized. A prescriber determines the appropriate strength, frequency, and duration based on the patient’s condition, age, response, and tolerance. Patients should follow the specific instructions provided by their healthcare professional and not adjust the dose on their own.

The safety of amitriptyline during pregnancy and lactation is not well established. Healthcare providers weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives and precautions with their physician.

To request Laroxyl, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Laroxyl belongs to the tricyclic antidepressant class, which differs from selective serotonin reuptake inhibitors (SSRIs) and serotonin‑norepinephrine reuptake inhibitors (SNRIs) in its broader receptor profile. It may be more effective for certain chronic pain conditions but often has a higher incidence of anticholinergic side effects compared with newer agents.

Laroxyl should be stored at room temperature, below 25 °C (77 °F). Keep the tablets in their original packaging, protect them from moisture, heat, and direct sunlight to maintain stability and potency throughout the shelf life.

Laroxyl is taken orally, usually as a tablet, with or without food as directed by a prescriber. The exact timing (e.g., morning or bedtime) depends on the therapeutic goal and the patient’s tolerance to potential drowsiness.

Serious risks include cardiac arrhythmias, especially in patients with pre‑existing heart disease, seizures at high doses, severe hypotension, and rare cases of blood dyscrasias or hepatic toxicity. Prompt medical attention is required if any alarming symptoms develop.

Laroxyl is contraindicated in individuals with known hypersensitivity to amitriptyline or other tricyclic antidepressants, recent use of monoamine oxidase inhibitors, and patients with certain cardiac conduction disorders. It should also be used with caution in the elderly and those with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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