Product image of Larvin (Clopidogrel) supplied by GNH India

Larvin

Active Ingredient:
Clopidogrel
Origin:
EU

Larvin (Clopidogrel)

Clopidogrel, the active ingredient in Larvin, is an antiplatelet agent presented as an oral tablet for systemic use. It inhibits platelet aggregation and is used to reduce the risk of atherothrombotic events in patients with cardiovascular disease.
GNH India supplies Larvin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmex S.A.

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Indications & Clinical Uses

Clopidogrel is indicated for conditions involving platelet‑mediated arterial thrombosis.

  • Acute coronary syndrome: lowers the risk of recurrent myocardial infarction and cardiovascular death.
  • Stroke prevention: reduces the incidence of ischemic stroke in patients with prior cerebrovascular events.
  • Peripheral arterial disease: improves walking distance and decreases limb‑related events.
  • Atherothrombotic event prevention: diminishes the likelihood of heart attack, stroke, or vascular death in high‑risk patients.

How It Works

  • Clopidogrel is an irreversible antagonist of the platelet P2Y12 ADP receptor. After hepatic conversion to its active metabolite, it blocks ADP‑mediated activation of the GPIIb/IIIa complex, preventing fibrinogen binding and subsequent platelet aggregation, thereby reducing thrombus formation in arterial circulation.

Side Effects

Clopidogrel may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bleeding gums or easy bruising
  • Diarrhea or abdominal discomfort
  • Nausea or vomiting
  • Headache
  • Rash or pruritus

Serious or Rare Side Effects

  • Severe or uncontrolled bleeding
  • Thrombotic thrombocytopenic purpura
  • Neutropenia or agranulocytosis
  • Hepatic failure or transaminase elevation
  • Severe allergic reactions including anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before initiating therapy, clinicians should evaluate bleeding risk and monitor patients regularly.

  • Assess bleeding risk: review history of gastrointestinal ulcers or hemorrhage.
  • Monitor platelet function: periodic laboratory checks may be warranted.
  • Review concomitant anticoagulants: adjust therapy to avoid excessive bleeding.
  • Adjust in hepatic impairment: use with caution in patients with liver disease.
  • Avoid in active pathological bleeding: discontinue if severe bleeding occurs.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Clopidogrel interacts with several drug classes that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Proton pump inhibitors (e.g., omeprazole): may reduce clopidogrel activation.
  • Strong CYP2C19 inhibitors (e.g., fluoxetine, ticagrelor): decrease conversion to active metabolite.
  • Anticoagulants (e.g., warfarin, heparin): increase risk of major bleeding.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may lower plasma levels.
  • Non‑steroidal anti‑inflammatory drugs (e.g., ibuprofen): add to bleeding risk.

Frequently Asked Questions

Larvin, containing clopidogrel, is prescribed to reduce the risk of atherothrombotic events such as heart attack, ischemic stroke, and peripheral arterial disease. It is commonly used in patients with acute coronary syndrome, a history of myocardial infarction, or those who have undergone coronary stenting.

Clopidogrel is converted in the liver to an active metabolite that irreversibly blocks the P2Y12 ADP receptor on platelets. This inhibition prevents ADP‑mediated activation of the GPIIb/IIIa complex, reducing fibrinogen binding and platelet aggregation, thereby limiting arterial clot formation.

The appropriate dose of Larvin is determined by the prescribing clinician based on the patient’s medical condition, renal and hepatic function, and concomitant therapies. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Clopidogrel is generally not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding; therefore, the drug should be used with caution and only if clearly needed, after consulting a healthcare professional.

To place an order, submit an enquiry on the Larvin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Larvin (clopidogrel) is a thienopyridine class antiplatelet that provides irreversible P2Y12 inhibition, whereas agents like aspirin act on cyclooxygenase‑1. Compared with newer agents such as ticagrelor, clopidogrel has a longer onset of action and may be affected by CYP2C19 genetic variability, but it remains widely used due to its established efficacy and safety profile.

Larvin tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Larvin is taken orally, usually with or without food, as a whole tablet. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare provider.

The most serious risks include severe or uncontrolled bleeding, thrombotic thrombocytopenic purpura, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience unusual bruising, blood in urine or stool, or signs of an allergic reaction.

Larvin should not be used by individuals with active pathological bleeding, a known hypersensitivity to clopidogrel or any component of the formulation, or severe hepatic impairment. Caution is also advised in patients with a history of hemorrhagic stroke or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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