Larymed (Benzydamine Hydrochloride)

Benzydamine Hydrochloride acts locally on inflamed oral and pharyngeal tissues, providing anti‑inflammatory and analgesic effects.

• Sore throat: reduces pain and inflammation in acute pharyngitis.
• Oral mucositis: alleviates discomfort associated with chemotherapy‑induced mucosal lesions.
• Gingivitis: diminishes swelling and bleeding of the gums.
• Stomatitis: eases irritation and burning sensations in the oral cavity.

• Benzydamine Hydrochloride inhibits prostaglandin synthesis by blocking cyclooxygenase activity in the oral mucosa, while also exerting local anesthetic and membrane‑stabilising actions that reduce nociceptor activation and inflammatory mediator release, leading to rapid symptom relief.

Benzydamine Hydrochloride is generally well tolerated when used as directed, but local adverse reactions can occur.

Common Side Effects

• Mild burning or stinging sensation at the site of application.
• Transient taste alteration or metallic taste.
• Local numbness or tingling.
• Mild irritation or redness of the oral mucosa.
• Dry mouth.
• Temporary increase in salivation.

Serious or Rare Side Effects

• Allergic reactions such as rash, urticaria or angioedema.
• Severe mucosal ulceration or necrosis.
• Anaphylactic shock (rare).
• Persistent swelling of the tongue or throat.
• Systemic hypersensitivity reactions.
• Unexplained fever or chills.

Before using Larymed, consider the following safety measures.

• Contraindication: Do not use if you have a known hypersensitivity to benzydamine or any excipients.
• Pregnancy: Use only if clearly needed and prescribed, as safety data are limited.
• Breastfeeding: Consult a healthcare professional before use.
• Children: Safety and efficacy have not been established for pediatric patients.
• Interaction with other oral medications: Rinse mouth after using other topical agents to avoid additive irritation.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Benzydamine Hydrochloride may interact with other agents that affect bleeding, irritation or systemic absorption.

Major Interactions (Avoid)

• Concurrent use of other NSAIDs: increased risk of local irritation and mucosal damage.
• Anticoagulants (e.g., warfarin): potential for enhanced bleeding in the oral cavity.

Moderate Interactions (Monitor Closely)

• Alcohol consumption: may worsen mucosal irritation.
• Corticosteroid mouth rinses: could potentiate local tissue thinning.
• Other topical anesthetics: risk of additive numbness.
• Herbal products with antiplatelet activity: monitor for bleeding.