Product image of Lasilix Special (Furosemide) supplied by GNH India

Lasilix Special

Active Ingredient:
Furosemide
Origin:
EU

Lasilix Special (Furosemide)

Furosemide, the active ingredient in Lasilix Special, is a loop diuretic presented as an injectable solution for intravenous use. It reduces fluid overload in patients with edema and helps control high blood pressure.

GNH India supplies Lasilix Special as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Lasilix Special (furosemide) is used to manage conditions involving fluid retention and elevated blood pressure.

  • Edema associated with congestive heart failure: helps remove excess fluid, improving breathing and reducing swelling.
  • Edema associated with liver cirrhosis: promotes diuresis to lessen abdominal distension and peripheral edema.
  • Edema associated with renal disease: facilitates fluid removal when kidney function is impaired.
  • Hypertension: lowers blood pressure by decreasing circulating plasma volume.

How It Works

  • Furosemide inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the thick ascending limb of the loop of Henle, leading to reduced reabsorption of sodium, chloride, and potassium. This disruption increases urinary excretion of these electrolytes together with water, producing a potent diuretic effect that decreases extracellular fluid volume and systemic vascular resistance.

Side Effects

Lasilix Special may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Increased urinary frequency: heightened urine output.
  • Electrolyte imbalance (e.g., hypokalemia): low potassium levels.
  • Dizziness or light‑headedness: due to volume depletion.
  • Headache: often related to blood pressure changes.
  • Dehydration: excessive fluid loss.
  • Hypotension: drop in blood pressure.

Serious or Rare Side Effects

  • Ototoxicity: hearing loss or ringing, especially with rapid IV administration.
  • Severe electrolyte disturbances: hypernatremia, hypocalcemia.
  • Acute renal failure: sudden decline in kidney function.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Thrombocytopenia: low platelet count.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Before using Lasilix Special, consider the following safety measures.

  • Monitor electrolytes: check serum potassium, sodium, and magnesium regularly.
  • Assess renal function: evaluate creatinine and urine output before and during therapy.
  • Adjust dose in hepatic impairment: reduce dosage if liver disease is present.
  • Use cautiously in hypotension: avoid rapid infusion in patients with low blood pressure.
  • Avoid abrupt discontinuation: taper to prevent rebound fluid retention.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lasilix Special can interact with several medicines; awareness helps prevent complications.

Major Interactions (Avoid)

  • NSAIDs: may blunt diuretic response.
  • Aminoglycoside antibiotics: increase risk of ototoxicity.
  • Lithium: can raise lithium serum levels, leading to toxicity.
  • Other potent loop diuretics: additive nephrotoxic effects.
  • Cyclosporine: may enhance nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may cause excessive blood pressure reduction.
  • Beta‑blockers: can potentiate hypotensive effects.
  • Digoxin: electrolyte shifts may predispose to arrhythmias.
  • Corticosteroids: may increase fluid loss.
  • Antihypertensives: monitor for additive hypotension.

Frequently Asked Questions

Lasilix Special contains furosemide, a loop diuretic indicated for the treatment of edema related to congestive heart failure, liver cirrhosis, and renal disease, as well as for the management of hypertension. It works by promoting the excretion of excess fluid and salts, helping to relieve swelling and lower blood pressure in affected patients.

Furosemide blocks the Na⁺/K⁺/2Cl⁻ cotransporter in the thick ascending limb of the loop of Henle. By inhibiting this transporter, it reduces the reabsorption of sodium, chloride, and potassium, leading to increased urinary loss of these electrolytes together with water. The resulting diuresis decreases extracellular fluid volume and systemic vascular resistance.

The dose of Lasilix Special is individualized by the prescribing clinician based on the patient’s medical condition, severity of fluid overload, renal function, and response to therapy. Typical dosing ranges for intravenous administration vary, and the prescriber will determine the appropriate amount, frequency, and duration for each patient.

Safety data for furosemide in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefits outweigh the possible risks to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Lasilix Special product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Lasilix Special (furosemide) is a loop diuretic, offering a more potent and rapid diuretic effect than thiazide diuretics, which act on the distal convoluted tubule. Loop diuretics are preferred for severe edema and acute fluid overload, whereas thiazides are often used for milder hypertension. The choice depends on the clinical scenario, renal function, and desired speed of fluid removal.

Lasilix Special should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Ensure the container is tightly sealed when not in use, and keep it out of reach of children. Do not freeze the product, and discard any solution that appears discolored or contains particles.

Lasilix Special is administered intravenously. The solution is typically given as a slow infusion or bolus injection, depending on the clinical indication and patient condition. Administration should be performed by qualified healthcare personnel in a setting equipped for monitoring vital signs and electrolyte levels, with appropriate dilution and infusion equipment as recommended in the product’s prescribing information.

The most serious risks include ototoxicity, which can cause hearing loss especially with rapid IV administration; severe electrolyte disturbances such as hypokalemia, hyponatremia, or hyperuricemia; acute renal failure due to excessive volume depletion; and hypersensitivity reactions that may lead to anaphylaxis. Prompt monitoring of renal function, electrolytes, and auditory status is essential during therapy.

Lasilix Special is contraindicated in patients with anuria (no urine output), known hypersensitivity to furosemide or other sulfonamide-derived drugs, and those with severe electrolyte depletion that cannot be corrected. Caution is also advised for individuals with severe hepatic impairment, uncontrolled hypotension, or active ototoxicity. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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