Product image of Lasium (Rivastigmine) supplied by GNH India

Lasium

Active Ingredient:
Rivastigmine
Origin:
EU

Lasium (Rivastigmine)

Rivastigmine, the active ingredient in Lasium, is an acetylcholinesterase inhibitor presented as an oral formulation for oral use. It is indicated for mild to moderate dementia associated with Alzheimer’s disease and Parkinson’s disease.
GNH India supplies Lasium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Innovis Pharma

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Indications & Clinical Uses

Rivastigmine acts on the cholinergic pathway to improve cognition in several dementia syndromes.

  • Alzheimer’s disease dementia: improves cognitive function and daily activities in mild to moderate stages.
  • Parkinson’s disease dementia: helps maintain cognition and functional abilities.
  • Mild to moderate dementia of other etiologies: may provide symptomatic benefit.

How It Works

  • Rivastigmine reversibly inhibits both acetylcholinesterase and butyrylcholinesterase enzymes, reducing the breakdown of acetylcholine in the central nervous system. The resulting increase in synaptic acetylcholine enhances cholinergic neurotransmission, which is associated with improved memory, attention, and overall cognitive performance in dementia patients.

Side Effects

Rivastigmine may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional, often transient.
  • Diarrhea: loose stools that may affect hydration.
  • Loss of appetite: reduced food intake.
  • Weight loss: gradual decrease in body weight.
  • Abdominal pain: discomfort in the stomach area.

Serious or Rare Side Effects

  • Severe vomiting: may lead to dehydration.
  • Gastrointestinal bleeding: rare but potentially life‑threatening.
  • Bradycardia: markedly slow heart rate.
  • Syncope: fainting episodes.
  • Severe skin reactions: such as rash or Stevens‑Johnson syndrome.
  • Elevated liver enzymes: indicating possible hepatic involvement.

Precautions & Warnings

Before initiating Lasium, clinicians should consider several safety measures.

  • Dose titration: start low and increase gradually to improve tolerance.
  • Gastrointestinal monitoring: watch for persistent nausea or vomiting.
  • Cardiovascular assessment: evaluate heart rate and blood pressure regularly.
  • Renal/hepatic function: adjust use in patients with impairment.
  • Drug interaction review: assess concomitant medications for cholinergic or anticholinergic effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Rivastigmine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticholinergic drugs: may reduce therapeutic efficacy.
  • Beta‑blockers: can increase risk of bradycardia.
  • Other cholinesterase inhibitors: additive cholinergic effects may be unsafe.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened risk of gastrointestinal bleeding.
  • SSRIs and other antidepressants: may increase nausea.
  • Antihypertensives: potential enhancement of hypotensive effects.

Frequently Asked Questions

Lasium contains rivastigmine and is prescribed to treat mild to moderate dementia associated with Alzheimer’s disease and Parkinson’s disease. It helps improve cognition, memory, and daily functioning by enhancing cholinergic activity in the brain.

Rivastigmine reversibly inhibits acetylcholinesterase and butyrylcholinesterase, enzymes that break down acetylcholine. By slowing this breakdown, the drug raises acetylcholine levels in the central nervous system, supporting neurotransmission that is typically reduced in dementia.

The specific dose of Lasium is determined by the prescribing clinician based on the patient’s condition, age, renal function, and tolerance. Dosage adjustments are made gradually to balance efficacy with potential side effects.

Safety data for rivastigmine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Lasium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lasium (rivastigmine) is a reversible inhibitor of both acetylcholinesterase and butyrylcholinesterase, whereas other agents like donepezil target primarily acetylcholinesterase. This broader inhibition can offer additional symptomatic benefit for some patients, but the side‑effect profile may differ, requiring individualized selection by the prescriber.

Store Lasium at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Lasium is taken orally, usually with food to lessen gastrointestinal irritation. The tablet (or oral formulation) should be swallowed whole with a glass of water unless otherwise directed by a healthcare professional.

Serious risks include severe vomiting, gastrointestinal bleeding, marked bradycardia, syncope, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Lasium is contraindicated in patients with known hypersensitivity to rivastigmine or any component of the formulation, and in those with severe cardiac conduction disorders or uncontrolled asthma. Caution is also advised for individuals with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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